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[恶性腹膜间皮瘤肿瘤。演变、治疗、预后]

[Malignant peritoneal mesothelioma tumours. Evolution, treatment, prognosis].

作者信息

Scripcariu V, Dajbog Elena, Radu I, Ferariu D, Pricop Adriana, Grigoraş M, Dragomir C

机构信息

Universitatea de Medicina şi Farmacie Gr. T. Popa Iaşi Facultatea de Medicină, Clinica a III-a Chirurgicală şi Centrul de Cercetare în Chirurgia Oncologică şi Training in Chirurgie Generală

出版信息

Rev Med Chir Soc Med Nat Iasi. 2007 Jul-Sep;111(3):673-7.

Abstract

Malignant mesothelioma of the peritoneum is a rare neoplasm with a rapidly fatal course. The median survival range is from 5 to 12 months in untreated cases with little improvement seen in patients receiving multimodality therapy. Although most cases occur in the fifth and sixth decades, peritoneal mesothelioma can be seen in any age group. Approximately 30% of all mesotheliomas arise solely from the peritoneum. Asbestos exposure, primarily of the crocidolite variety, has been implicated in the pathogenesis of this malignancy, as was established in South Africa in the 1960s. Half of reported cases have a history of asbestos exposure. The diagnosis of peritoneal mesothelioma is often delayed, in part because of the usually long latent period (peaking at 40-45 years from the time of initial exposure to asbestos) and because the common presenting symptoms of weight loss, usually with a full abdomen, malaise, and abdominal discomfort, are mild and nonspecific. This paper aim is to present a case report regarding a patient diagnosed with malignant peritoneal mesothelioma with an unpredictable evolution.

摘要

腹膜恶性间皮瘤是一种罕见的肿瘤,病程进展迅速,预后极差。未经治疗的患者中位生存期为5至12个月,接受多模式治疗的患者改善甚微。虽然大多数病例发生在五六十岁,但腹膜间皮瘤可见于任何年龄组。所有间皮瘤中约30%仅起源于腹膜。石棉暴露,主要是青石棉,在20世纪60年代的南非已证实与这种恶性肿瘤的发病机制有关。报告病例中有一半有石棉暴露史。腹膜间皮瘤的诊断常常延迟,部分原因是通常潜伏期较长(从最初接触石棉开始计算,在40至45岁达到高峰),且常见的症状如体重减轻、腹部胀满、不适和全身乏力等较为轻微且缺乏特异性。本文旨在报告一例诊断为恶性腹膜间皮瘤且病情发展不可预测的病例。

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