[血管性血友病患者的妊娠与分娩。附病例报告]

[Pregnancy and delivery in a patient with Willebrand's disease. Apropos of a case].

作者信息

Cherkaoui S, Laaloui A, Faiz S, Benchemsi N

机构信息

Laboratoire d'hématologie, CHU Ibn Rochd, Casablanca, Maroc.

出版信息

Transfus Clin Biol. 2007 Nov;14(5):474-80. doi: 10.1016/j.tracli.2007.12.004. Epub 2008 Mar 4.

DOI:10.1016/j.tracli.2007.12.004

PMID:18295527

Abstract

Willebrand's disease is the most frequent inborn coagulopathy and type 3 is its most severe form. Pregnancy and delivery are critical events in women with Willebrand's disease of type 3. Prophylactic treatment for delivery and early postpartum period is recommended. We report the management of pregnancy and successful delivery of a 32-year-old woman with type 3. Prophylactic treatment with 2000 IU of Willebrand's disease factor (WdF) was given twice a day during the delivery day and the day after, and 1000 IU per day during the next three days. The patient did not show any spontaneous metrorrhagia but anemia. No bleeding was observed in the newborn.

摘要

血管性血友病是最常见的先天性凝血障碍，3型是其最严重的形式。妊娠和分娩对于患有3型血管性血友病的女性来说是关键事件。建议在分娩期和产后早期进行预防性治疗。我们报告了一名32岁3型血管性血友病女性的妊娠管理及成功分娩情况。在分娩当天及次日，每天两次给予2000国际单位的血管性血友病因子（WdF）进行预防性治疗，接下来三天每天给予1000国际单位。患者未出现任何自发性子宫出血，但有贫血。新生儿未观察到出血情况。