造血作用：干细胞生物学的一个不断发展的范式。
Hematopoiesis: an evolving paradigm for stem cell biology.
作者信息
Orkin Stuart H, Zon Leonard I
机构信息
Division of Hematology/Oncology, Children's Hospital Boston and the Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell. 2008 Feb 22;132(4):631-44. doi: 10.1016/j.cell.2008.01.025.
Abstract
Establishment and maintenance of the blood system relies on self-renewing hematopoietic stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult mammals. This Review describes the developmental origins of HSCs and the molecular mechanisms that regulate lineage-specific differentiation. Studies of hematopoiesis provide critical insights of general relevance to other areas of stem cell biology including the role of cellular interactions in development and tissue homeostasis, lineage programming and reprogramming by transcription factors, and stage- and age-specific differences in cellular phenotypes.
摘要
血液系统的建立和维持依赖于自我更新的造血干细胞（HSCs），这些细胞通常少量存在于成年哺乳动物骨髓微环境中。本综述描述了造血干细胞的发育起源以及调节谱系特异性分化的分子机制。造血研究为干细胞生物学的其他领域提供了重要的见解，包括细胞相互作用在发育和组织稳态中的作用、转录因子对谱系的编程和重编程，以及细胞表型的阶段和年龄特异性差异。
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