产气荚膜梭菌外毒素。III. θ毒素与红细胞膜的结合。
Clostridium perfringens exotoxins. III. Binding of theta-toxin to erythrocyte membrane.
作者信息
Hase J, Mitsui K, Shonaka E
出版信息
Jpn J Exp Med. 1975 Dec;45(6):433-8.
PMID:183032
Abstract
When Clostridium perfringens theta-toxin was incubated with sheep erythrocytes the toxin activity disappeared before lysis, the fact of which suggests fixation of the toxin to erythrocyte membranes. 2. Theta-Toxin lost its activity by binding to cell membranes, and the membrane constituted inhibitor of theta-hemolysis was neither a protein, a carbohydrate nor a phosphatide, but was cholesterol. From these results this report proposes that the theta-toxin binding site of erythrocytes should be cholesterol.
摘要
当产气荚膜梭菌θ毒素与绵羊红细胞一起孵育时，毒素活性在细胞裂解前就消失了，这一事实表明毒素与红细胞膜发生了结合。2. θ毒素通过与细胞膜结合而丧失活性，构成θ溶血抑制剂的膜成分既不是蛋白质、碳水化合物，也不是磷脂，而是胆固醇。基于这些结果，本报告提出红细胞的θ毒素结合位点应为胆固醇。
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Clostridium perfringens exotoxins. III. Binding of theta-toxin to erythrocyte membrane.产气荚膜梭菌外毒素。III. θ毒素与红细胞膜的结合。
Jpn J Exp Med. 1975 Dec;45(6):433-8.
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Infect Immun. 1982 Mar;35(3):1086-90. doi: 10.1128/iai.35.3.1086-1090.1982.
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Interaction of streptolysin O from Streptococcus pyogenes and theta-toxin from Clostridium perfringens with human fibroblasts.化脓性链球菌的链球菌溶血素O与产气荚膜梭菌的θ毒素与人成纤维细胞的相互作用。
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