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酷似妊娠合并肺炎的肺癌

Lung cancer mimicking as pregnancy with pneumonia.

作者信息

Mehta Hiren, Bahuva Rubin, Sadikot Ruxana T

机构信息

Cook County Hospital, Chicago, IL, United States.

出版信息

Lung Cancer. 2008 Sep;61(3):416-9. doi: 10.1016/j.lungcan.2007.12.026. Epub 2008 Mar 4.

Abstract

Lung cancer that presents with secretion of beta HCG is rare. We report a case of a young female patient who presented with symptoms of pneumonia and was found to have a positive pregnancy test. With non-resolution of the consolidation and progression of her symptoms she subsequently was found to have large cell lung cancer with ectopic beta HCG secretion. Ectopic production of a variety of hormones such as ADH, parathyroid hormone, ACTH, insulin-like growth factor thus leading to presentation as endocrine syndromes in patients with lung cancer is well known. The presentation of lung cancer mimicking as pregnancy has not been previously reported. This case illustrates the importance of considering the possibility of paraneoplastic secretion of beta HCG in female patients who have a positive pregnancy test in an appropriate clinical setting. This may prevent a delay in the diagnosis and treatment of malignancy in young women.

摘要

表现为β-HCG分泌的肺癌很罕见。我们报告一例年轻女性患者,该患者最初表现为肺炎症状,妊娠试验呈阳性。随着肺部实变未消退且症状进展,随后发现她患有伴有异位β-HCG分泌的大细胞肺癌。众所周知,肺癌患者会异位产生多种激素,如抗利尿激素、甲状旁腺激素、促肾上腺皮质激素、胰岛素样生长因子等,从而导致出现内分泌综合征。此前尚未有肺癌表现类似妊娠的报道。该病例说明了在适当临床环境下,对于妊娠试验呈阳性的女性患者,考虑副肿瘤性分泌β-HCG可能性的重要性。这可能会避免年轻女性恶性肿瘤诊断和治疗的延误。

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