Carlin Arthur M, Yager Kelli M, Rao D Sudhaker
Department of Surgery, Henry Ford Hospital Detroit, MI, USA.
Am J Surg. 2008 Mar;195(3):349-52; discussion 352. doi: 10.1016/j.amjsurg.2007.12.016.
Morbid obesity is a risk factor for hypertension (HTN) and vitamin D (VitD) depletion. Gastric bypass (GBP) resolves HTN in many patients. The goal of this study was to evaluate the potential role of VitD nutritional status on HTN resolution in patients undergoing GBP.
A retrospective review of morbidly obese patients taking antihypertensive medications and undergoing GBP from September 1, 2002, through February 28, 2006 was performed.
At 1 year postoperatively HTN resolved in 53%, improved in 36%, and was unchanged in 11%. Sex, race, body mass index, and percentage of excess weight loss did not impact HTN resolution. Younger patients experienced a greater rate of HTN resolution. Patients with VitD depletion had significantly lower rates of HTN resolution compared to those with adequate levels of VitD (42% vs 61%; P = .008).
VitD nutritional status impacts the resolution rate of HTN after GBP. All morbidly obese patients undergoing GBP should be monitored and treated for VitD depletion.
病态肥胖是高血压（HTN）和维生素D（VitD）缺乏的危险因素。胃旁路手术（GBP）可使许多患者的高血压得到缓解。本研究的目的是评估VitD营养状况在接受GBP手术的患者高血压缓解中的潜在作用。
对2002年9月1日至2006年2月28日期间服用抗高血压药物并接受GBP手术的病态肥胖患者进行回顾性研究。
术后1年，53%的患者高血压得到缓解，36%的患者有所改善，11%的患者无变化。性别、种族、体重指数和超重减轻百分比对高血压缓解无影响。年轻患者的高血压缓解率更高。与VitD水平充足的患者相比，VitD缺乏的患者高血压缓解率显著更低（42%对61%；P = 0.008）。
VitD营养状况影响GBP术后高血压的缓解率。所有接受GBP手术的病态肥胖患者都应监测并治疗VitD缺乏。
