维生素D缺乏会损害 Roux-en-Y 胃旁路术后高血压的缓解。
Vitamin D depletion impairs hypertension resolution after Roux-en-Y gastric bypass.
作者信息
Carlin Arthur M, Yager Kelli M, Rao D Sudhaker
机构信息
Department of Surgery, Henry Ford Hospital Detroit, MI, USA.
出版信息
Am J Surg. 2008 Mar;195(3):349-52; discussion 352. doi: 10.1016/j.amjsurg.2007.12.016.
BACKGROUND
Morbid obesity is a risk factor for hypertension (HTN) and vitamin D (VitD) depletion. Gastric bypass (GBP) resolves HTN in many patients. The goal of this study was to evaluate the potential role of VitD nutritional status on HTN resolution in patients undergoing GBP.
METHODS
A retrospective review of morbidly obese patients taking antihypertensive medications and undergoing GBP from September 1, 2002, through February 28, 2006 was performed.
RESULTS
At 1 year postoperatively HTN resolved in 53%, improved in 36%, and was unchanged in 11%. Sex, race, body mass index, and percentage of excess weight loss did not impact HTN resolution. Younger patients experienced a greater rate of HTN resolution. Patients with VitD depletion had significantly lower rates of HTN resolution compared to those with adequate levels of VitD (42% vs 61%; P = .008).
CONCLUSIONS
VitD nutritional status impacts the resolution rate of HTN after GBP. All morbidly obese patients undergoing GBP should be monitored and treated for VitD depletion.
背景
病态肥胖是高血压（HTN）和维生素D（VitD）缺乏的危险因素。胃旁路手术（GBP）可使许多患者的高血压得到缓解。本研究的目的是评估VitD营养状况在接受GBP手术的患者高血压缓解中的潜在作用。
方法
对2002年9月1日至2006年2月28日期间服用抗高血压药物并接受GBP手术的病态肥胖患者进行回顾性研究。
结果
术后1年，53%的患者高血压得到缓解，36%的患者有所改善，11%的患者无变化。性别、种族、体重指数和超重减轻百分比对高血压缓解无影响。年轻患者的高血压缓解率更高。与VitD水平充足的患者相比，VitD缺乏的患者高血压缓解率显著更低（42%对61%；P = 0.008）。
结论
VitD营养状况影响GBP术后高血压的缓解率。所有接受GBP手术的病态肥胖患者都应监测并治疗VitD缺乏。
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