Tsyv'ian P B, Kovtun O P
Usp Fiziol Nauk. 2008 Jan-Mar;39(1):68-75.
The intrauterine programming hypothesis proposed that cardiovascular and metabolic disease originate through developmental plasticity and fetal adaptation arising from failure of the materno-placental supply of nutrients. The hypothesis is supported by experimental data in animals indicating that maternal nutrition can program long term effects on the offspring. The intrauterine conditions in which the fetus develops have an important role in regulating the function of its physiological systems later in life. Intrauterine programming of physiological systems occurs at the gene, cell, tissue, organ, and system levels and causes permanent structural and functional changes, which can lead to overt disease, particularly with increasing age. The physiological prevention of disease programming is discussing.
宫内编程假说提出，心血管疾病和代谢性疾病源于发育可塑性以及因母胎-胎盘营养供应不足而产生的胎儿适应性变化。该假说得到了动物实验数据的支持，这些数据表明母体营养可对后代产生长期影响。胎儿发育所处的宫内环境在调节其生理系统日后的功能方面起着重要作用。生理系统的宫内编程发生在基因、细胞、组织、器官和系统层面，并会导致永久性的结构和功能变化，这可能会引发显性疾病，尤其是随着年龄增长。目前正在探讨对疾病编程的生理预防措施。
