相似文献
1
Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs.
Bioorg Med Chem Lett. 2008 Mar 15;18(6):1889-92. doi: 10.1016/j.bmcl.2008.02.014. Epub 2008 Feb 12.
2
Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3499-502. doi: 10.1016/j.bmcl.2016.06.034. Epub 2016 Jun 16.
3
Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3503-7. doi: 10.1016/j.bmcl.2016.06.035. Epub 2016 Jun 15.
4
Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I.
Bioorg Med Chem Lett. 2001 Jun 18;11(12):1605-8. doi: 10.1016/s0960-894x(01)00292-x.
5
Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II.
Biochemistry. 2001 Jan 9;40(1):268-74. doi: 10.1021/bi002034p.
6
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors.
Farmaco. 2004 Nov;59(11):887-92. doi: 10.1016/j.farmac.2004.08.002.
7
Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.
Bioorg Med Chem Lett. 2003 Dec 15;13(24):4405-8. doi: 10.1016/j.bmcl.2003.09.035.
8
New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs.
Org Lett. 2011 Jul 15;13(14):3576-9. doi: 10.1021/ol201069x. Epub 2011 Jun 23.
9
Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II.
Biochemistry. 2000 Oct 3;39(39):12043-52. doi: 10.1021/bi000835m.
10
Coupling of isoprenoid triflates with organoboron nucleophiles: synthesis and biological evaluation of geranylgeranyl diphosphate analogues.
Bioorg Med Chem. 2002 May;10(5):1207-19. doi: 10.1016/s0968-0896(01)00390-x.
引用本文的文献
1
Regulation of Small GTPase Prenylation in the Nervous System.
Mol Neurobiol. 2020 May;57(5):2220-2231. doi: 10.1007/s12035-020-01870-0. Epub 2020 Jan 27.
2
Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3499-502. doi: 10.1016/j.bmcl.2016.06.034. Epub 2016 Jun 16.
3
Electrophilic aromatic prenylation via cascade cyclization.
Tetrahedron. 2013 Oct 4;69(44):9212-9218. doi: 10.1016/j.tet.2013.08.056.
4
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Pharmacol Ther. 2014 Jul;143(1):87-110. doi: 10.1016/j.pharmthera.2014.02.007. Epub 2014 Feb 26.
5
A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells.
J Pharmacol Exp Ther. 2010 Apr;333(1):23-33. doi: 10.1124/jpet.109.160192. Epub 2010 Jan 19.
本文引用的文献
1
Combinatorial modulation of protein prenylation.
ACS Chem Biol. 2007 Jun 15;2(6):385-9. doi: 10.1021/cb700062b. Epub 2007 May 25.
2
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.
J Clin Invest. 2007 May;117(5):1294-304. doi: 10.1172/JCI30868.
3
Geranylgeranyltransferase I as a target for anti-cancer drugs.
J Clin Invest. 2007 May;117(5):1223-5. doi: 10.1172/JCI32108.
4
Small-molecule inhibitors of protein geranylgeranyltransferase type I.
J Am Chem Soc. 2007 May 9;129(18):5843-5. doi: 10.1021/ja070274n. Epub 2007 Apr 17.
5
Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.
Bioorg Med Chem Lett. 2007 May 1;17(9):2639-42. doi: 10.1016/j.bmcl.2007.01.097. Epub 2007 Feb 2.
6
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.
Biochem Biophys Res Commun. 2007 Feb 23;353(4):921-5. doi: 10.1016/j.bbrc.2006.12.094. Epub 2006 Dec 21.
7
Multilevel modulation of the mevalonate and protein-prenylation circuitries as a novel strategy for anticancer therapy.
Trends Pharmacol Sci. 2007 Jan;28(1):6-13. doi: 10.1016/j.tips.2006.11.005. Epub 2006 Dec 5.
8
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition.
ChemMedChem. 2006 Feb;1(2):218-24. doi: 10.1002/cmdc.200500010.
9
Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.
Org Biomol Chem. 2006 May 7;4(9):1768-84. doi: 10.1039/b517572k. Epub 2006 Mar 21.
10
A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.
J Biol Chem. 2006 May 5;281(18):12445-50. doi: 10.1074/jbc.M600168200. Epub 2006 Mar 3.
Zotero 插件