具有通过酰胺主链连接的发色团单元的低聚物的设计、合成及抗增殖性能
Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones.
作者信息
Farrera-Sinfreu Josep, Aviñó Anna, Navarro Isabel, Aymamí Juan, Beteta Natàlia G, Varón Sònia, Pérez-Tomás Ricardo, Castillo-Avila Wilmar, Eritja Ramon, Albericio Fernando, Royo Miriam
机构信息
Combinatorial Chemistry Unit, Barcelona Scientific Park (PCB), Josep Samitier 1-5, E-08028 Barcelona, Spain.
出版信息
Bioorg Med Chem Lett. 2008 Apr 1;18(7):2440-4. doi: 10.1016/j.bmcl.2008.02.045. Epub 2008 Mar 5.
The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity.
本文描述了由几个发色团单元组成的低聚物的制备，这些低聚物作为具有潜在荧光和抗增殖特性的化合物。具体而言，描述了具有保护氨基和一个羧基的发色团单元，以及使用肽化学组装这些单元的方法。其中一些化合物具有抗增殖活性。
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