Salam Abdul, Sanmuganathan Phil, Pycock Chris
Specialist Registrar Geriatric/General Medicine, Worcester Royal Hospital, Worcester, UK.
J Med Case Rep. 2008 Mar 7;2:75. doi: 10.1186/1752-1947-2-75.
We report a case of a patient presenting with neuropsychiatric manifestations secondary to paradoxical embolism
Unexplained rapid onset of confusion with amnesia and minimal neurological deficits can be a manifestation of various systemic causes of which stroke, either ischemic or hemorrhagic, is one. Thorough and systematic evaluation of these patients can be highly rewarding in terms of optimizing patient outcome. We report the case of a 45-year-old woman whose initial presentation was with acute onset of confusion, memory loss with personality change and headaches. A differential diagnosis of systemic illness and cerebral pathology was entertained. She was empirically treated for neurological infection. Brain imaging revealed bilateral thalamic and cerebellar infarction. Further evaluation with an aim to define the etiology, revealed the diagnosis of Patent Foramen Ovale with paradoxical embolism. The differential diagnosis of unexplained rapid onset of confusion, amnesia with minimal motor neurological deficits and relevant appropriate investigations are discussed in this case report.
This case highlights the importance of recognising the atypical manifestations of posterior fossa stroke. In young patients presenting with non-focal neuropsychiatric manifestations, paradoxical embolism, secondary to patent foramen ovale is a possible cause.
我们报告一例因反常栓塞继发神经精神症状的患者。
原因不明的快速出现的意识模糊伴失忆且神经功能缺损轻微,可能是多种全身性病因的表现,其中缺血性或出血性中风是病因之一。对这些患者进行全面系统的评估,在优化患者预后方面可能会有很大收获。我们报告一例45岁女性,其最初表现为急性意识模糊、记忆力丧失伴人格改变及头痛。考虑了全身性疾病和脑部病变的鉴别诊断。她接受了针对神经感染的经验性治疗。脑部影像学检查显示双侧丘脑和小脑梗死。进一步评估以明确病因,诊断为卵圆孔未闭伴反常栓塞。本病例报告讨论了原因不明的快速出现的意识模糊、失忆伴轻微运动神经功能缺损的鉴别诊断及相关的适当检查。
本病例强调了认识后颅窝中风非典型表现的重要性。在出现非局灶性神经精神症状的年轻患者中,卵圆孔未闭继发的反常栓塞是一个可能的病因。