Liu Jie, Wang Deyun, Zheng Qi, Lu Min, Arora Paramjit S
Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.
J Am Chem Soc. 2008 Apr 2;130(13):4334-7. doi: 10.1021/ja077704u. Epub 2008 Mar 11.
Herein we report the 1.15 A X-ray crystal structure of a short alpha-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived alpha-helix truly resembles the structure of canonical alpha-helices and provides unequivocal support for our helix nucleation strategy.
在此，我们报道了一种短α-螺旋的1.15埃X射线晶体结构，其中N端i和i + 4主链氢键被碳-碳键取代。该结构表明，源自氢键替代物（HBS）的α-螺旋与典型α-螺旋的结构极为相似，并为我们的螺旋成核策略提供了明确支持。
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