XRCC1基因多态性与膀胱癌易感性：一项荟萃分析。

XRCC1 genetic polymorphisms and bladder cancer susceptibility: a meta-analysis.

作者信息

Wang Chunyang, Sun Yan, Han Ruifa

机构信息

Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin, China.

出版信息

Urology. 2008 Oct;72(4):869-72. doi: 10.1016/j.urology.2007.12.059. Epub 2008 Mar 12.

DOI:10.1016/j.urology.2007.12.059

PMID:18336890

Abstract

OBJECTIVES

To examine the association between three x-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms (Arg(194)Trp, Arg(280)His, and Arg(399)Gln) and bladder cancer susceptibility.

METHODS

A comprehensive search was conducted to identify all case-control studies of XRCC1 polymorphisms and bladder cancer risk. Statistical analysis was performed with the software program Review Manage, version 4.2.

RESULTS

A total of 10 eligible reports, including 3749 cases and 3947 controls, were identified. For Arg(194)Trp (six studies, 3091 cases, 3219 controls), no evidence indicated that individuals carrying the variant genotypes (Trp/Trp + Arg/Trp), relative to those carrying the wild homozygote Arg/Arg genotype, had a decreased risk of bladder cancer (odds ratio [OR] 0.90, 95% confidence interval [CI] 0.77 to 1.05; P = 0.17). For Arg(280)His (three studies, 2547 cases, 1784 controls), individuals with His/His+Arg/His genotypes had no significant risk of bladder cancer, compared with those with the Arg/Arg genotype (OR 0.99, 95% CI 0.55 to 1.77; P = 0.97). For Arg(399)Gln (10 studies, 3729 cases, 3927 controls), the Gln/Gln genotype carriers did not have a decreased cancer risk compared with those individuals with the Arg/Arg genotype (OR 0.95, 95% CI 0.82 to 1.10; P = 0.48). Similarly, no associations were found in the recessive and dominant modeling (Gln/Gln versus Arg/Gln+Arg/Arg: OR 0.92, 95% CI 0.80 to 1.05; P = 0.23; Arg/Gln+Gln/Gln versus Arg/Arg: OR 1.04, 95% CI 0.95 to 1.14; P = 0.36).

CONCLUSIONS

No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility.

摘要

目的

研究X射线修复交叉互补基因1（XRCC1）的三种基因多态性（Arg(194)Trp、Arg(280)His和Arg(399)Gln）与膀胱癌易感性之间的关联。

方法

进行全面检索以识别所有关于XRCC1基因多态性与膀胱癌风险的病例对照研究。使用Review Manage 4.2软件程序进行统计分析。

结果

共识别出10篇合格报告，包括3749例病例和3947例对照。对于Arg(194)Trp（六项研究，3091例病例，3219例对照），没有证据表明携带变异基因型（Trp/Trp + Arg/Trp）的个体相对于携带野生纯合子Arg/Arg基因型的个体患膀胱癌的风险降低（比值比[OR]为0.90，95%置信区间[CI]为0.77至1.05；P = 0.17）。对于Arg(280)His（三项研究，2547例病例，1784例对照），与携带Arg/Arg基因型的个体相比，携带His/His + Arg/His基因型的个体患膀胱癌的风险无显著差异（OR为0.99，95% CI为0.55至1.77；P = 0.97）。对于Arg(399)Gln（十项研究，3729例病例，3927例对照），与携带Arg/Arg基因型的个体相比，携带Gln/Gln基因型的个体患癌风险没有降低（OR为0.95，95% CI为0.82至1.10；P = 0.48）。同样，在隐性和显性模型中未发现关联（Gln/Gln与Arg/Gln + Arg/Arg相比：OR为0.92，95% CI为0.80至1.05；P = 0.23；Arg/Gln + Gln/Gln与Arg/Arg相比：OR为1.04，95% CI为0.95至1.14；P = 0.36）。