Dalamaga Maria, Nikolaidou Athina, Karmaniolas Konstantinos, Hsi Alex, Chamberland John, Dionyssiou-Asteriou Amalia, Mantzoros Christos S
Department of Clinical Biochemistry, Medical School, University of Athens, Attikon General University Hospital, Chaidari, Greece.
Oncology. 2007;73(1-2):26-32. doi: 10.1159/000120995. Epub 2008 Mar 13.
Adiponectin plays a protective role in several malignancies, including myeloblastic leukemia, whereas leptin may increase the proliferation of progenitor cells and may stimulate leukemic cell growth in vitro. We investigated the role of adiponectin and leptin levels in the etiopathogenesis of myelodysplastic syndromes (MDS), a preleukemic condition with increasing incidence which has recently been associated with obesity.
In a case-control study, 101 cases with incident, histologically confirmed primary MDS and 101 controls matched on gender and age were studied between 2004 and 2007, and blood samples were collected.
Higher serum adiponectin levels were associated with lower risk of MDS by bivariate analysis and after adjusting for age, gender, body mass index and serum levels of leptin (p < 0.001). Subjects in the third quartile for leptin levels had a lower risk of MDS than controls, and low leptin concentrations were observed in low-risk MDS patients with normal or good prognostic karyotype after adjusting for age, gender and body mass index.
Circulating adiponectin and leptin may play an important role in MDS etiopathogenesis. Future studies are needed to confirm these associations and to explore underlying mechanisms.
脂联素在包括髓系白血病在内的多种恶性肿瘤中发挥保护作用，而瘦素可能会增加祖细胞的增殖，并在体外刺激白血病细胞生长。我们研究了脂联素和瘦素水平在骨髓增生异常综合征（MDS）发病机制中的作用，MDS是一种白血病前期疾病，发病率不断上升，最近被认为与肥胖有关。
在一项病例对照研究中，2004年至2007年期间对101例新诊断的、经组织学确诊的原发性MDS患者以及101例年龄和性别匹配的对照者进行了研究，并采集了血样。
通过双变量分析以及在调整年龄、性别、体重指数和瘦素血清水平后，较高的血清脂联素水平与较低的MDS风险相关（p < 0.001）。瘦素水平处于第三个四分位数的受试者患MDS的风险低于对照组，在调整年龄、性别和体重指数后，低风险MDS患者且核型正常或预后良好者的瘦素浓度较低。
循环脂联素和瘦素可能在MDS发病机制中发挥重要作用。需要进一步的研究来证实这些关联并探索潜在机制。
