无端假设：DNA对Toll样受体9（TLR9）的激活

Baseless assumptions: activation of TLR9 by DNA.

作者信息

Gangloff Monique, Gay Nicholas J

机构信息

Department of Biochemistry, Cambridge University, 80 Tennis Road, Cambridge CB2 1GA, UK.

出版信息

Immunity. 2008 Mar;28(3):293-4. doi: 10.1016/j.immuni.2008.02.009.

DOI:10.1016/j.immuni.2008.02.009

PMID:18342000

Abstract

The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent manner.

摘要

Toll样受体9（TLR9）由酸化的细胞内区室中呈现的DNA激活。先前的研究表明，信号传导需要未甲基化的CpG二核苷酸，但在本期《免疫》杂志中，哈斯等人（2008年）对这一观点提出了质疑，表明DNA可以以序列非依赖的方式激活TLR9。