Lévesque H
Département de médecine interne, CHU de Rouen, 76031 Rouen cedex, France.
Pathol Biol (Paris). 2008 Jun;56(4):205-10. doi: 10.1016/j.patbio.2008.01.002. Epub 2008 Mar 17.
The association between thrombosis and cancer, initially evidenced in metastatic patients is well recognized and now described in patients with occult cancer where venous thrombosis may be the first clinical manifestation (Trousseau's syndrome). In this review, clinical and epidemiological interactions between thrombosis and cancer are described in five distinct step: venous thrombosis during malignancy and occult cancer, period of large increased in the risk for diagnosis of cancer, patients or venous thrombosis with increased risk for occult cancer, extensive or not extensive screening for occult cancer, earlier occult cancer detection associated or not with improved treatment possibilities and thus prognosis.
血栓形成与癌症之间的关联最初在转移性患者中得到证实,现已在隐匿性癌症患者中得到描述,其中静脉血栓形成可能是首发临床表现(特鲁索综合征)。在本综述中,血栓形成与癌症之间的临床和流行病学相互作用分为五个不同阶段进行描述:恶性肿瘤和隐匿性癌症期间的静脉血栓形成、癌症诊断风险大幅增加的时期、静脉血栓形成且隐匿性癌症风险增加的患者、隐匿性癌症的广泛或非广泛筛查、隐匿性癌症的早期检测与改善治疗可能性及预后的关联与否。