Young S S, Eskenazi B, Marchetti F M, Block G, Wyrobek A J
School of Public Health, University of California, 2150 Shattuck Avenue, Suite 600, Berkeley, CA 94704-7380, USA.
Hum Reprod. 2008 May;23(5):1014-22. doi: 10.1093/humrep/den036. Epub 2008 Mar 19.
Little is known about the effect of paternal nutrition on aneuploidy in sperm. We investigated the association of normal dietary and supplement intake of folate, zinc and antioxidants (vitamin C, vitamin E and beta-carotene) with the frequency of aneuploidy in human sperm.
Sperm samples from 89 healthy, non-smoking men from a non-clinical setting were analysed for aneuploidy using fluorescent in situ hybridization with probes for chromosomes X, Y and 21. Daily total intake (diet and supplements) for zinc, folate, vitamin C, vitamin E and beta-carotene was derived from a food frequency questionnaire. Potential confounders were obtained from a self-administered questionnaire.
After adjusting for covariates, men with high folate intake (>75th percentile) had lower frequencies of sperm with disomies X, 21, sex nullisomy, and a lower aggregate measure of sperm aneuploidy (P <or= 0.04) compared with men with lower intake. In adjusted continuous analyses, total folate intake was inversely associated with aggregate sperm aneuploidy (-3.6% change/100 microg folate; 95% CI: -6.3, -0. 8) and results were similar for disomies X, 21 and sex nullisomy. No consistent associations were found between antioxidant or zinc intakes and sperm aneuploidy.
Men with high folate intake had lower overall frequencies of several types of aneuploid sperm.
关于父亲营养对精子非整倍体的影响，人们了解甚少。我们调查了正常饮食以及叶酸、锌和抗氧化剂（维生素C、维生素E和β-胡萝卜素）补充剂的摄入量与人类精子非整倍体频率之间的关联。
使用针对X、Y和21号染色体的探针，通过荧光原位杂交技术对来自非临床环境的89名健康、不吸烟男性的精子样本进行非整倍体分析。锌、叶酸、维生素C、维生素E和β-胡萝卜素的每日总摄入量（饮食和补充剂）来自食物频率问卷。潜在混杂因素通过自填问卷获取。
在对协变量进行调整后，与摄入量较低的男性相比，叶酸摄入量高（>第75百分位数）的男性精子X、21号染色体二体、性染色体单体的频率较低，精子非整倍体的综合测量值也较低（P≤0.04）。在调整后的连续分析中，总叶酸摄入量与精子非整倍体综合测量值呈负相关（每100微克叶酸变化-3.6%；95%置信区间：-6.3, -0.8），X、21号染色体二体和性染色体单体的结果相似。未发现抗氧化剂或锌摄入量与精子非整倍体之间存在一致的关联。
叶酸摄入量高的男性几种类型非整倍体精子的总体频率较低。
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