Matsuda M, Yanagisawa N, Tsukada N
Department of Medicine (Neurology), Shinshu University School of Medicine.
Arerugi. 1991 Sep;40(9):1226-31.
Recent clinical problems in patients with subacute myelo-optico-neuropathy (SMON) arise mainly from complications associated with the disease. Some of them show the association of autoimmune diseases. Furthermore, it has been reported that some kinds of autoantibody and hyperglobulinemia are frequently seen in patients with SMON. In order to examine whether ageing and clioquinol intoxication in the past may be implicated in the immunological system of the patients, we investigated subsets of peripheral blood lymphocytes including OKT3, OKT4, OKT8, OKIa1 and Leu7, in 31 patients with SMON, who lived in Nagano Prefecture. The levels of OKT8 (% positive cells), which are known to decrease with age actually increased with age in the peripheral blood of patients with SMON. The levels of OKT4 decreased with ageing, as did the OKT4/OKT8 ratios. The percentage of OKIa1 also significantly increased with age in the peripheral blood of patients with SMON compared to that of the controls (p less than 0.01 or p less than 0.001). It is considered unlikely that the effect of ageing on subsets of lymphocytes can be implicated in these immunological abnormalities of SMON patients, but it seems likely that the immune systems (B cell or T cell) of SMON patients are activated by factors other than ageing in subsets of lymphocytes.
亚急性脊髓视神经病变（SMON）患者近期出现的临床问题主要源于与该疾病相关的并发症。其中一些显示出与自身免疫性疾病有关。此外，据报道，在SMON患者中经常可以看到某些自身抗体和高球蛋白血症。为了研究过去的衰老和氯碘羟喹中毒是否可能与患者的免疫系统有关，我们调查了31名居住在长野县的SMON患者外周血淋巴细胞亚群，包括OKT3、OKT4、OKT8、OKIa1和Leu7。已知OKT8（阳性细胞百分比）会随着年龄增长而下降，但在SMON患者的外周血中实际上却随着年龄增长而增加。OKT4水平随着年龄增长而下降，OKT4/OKT8比值也是如此。与对照组相比，SMON患者外周血中OKIa1的百分比也随着年龄增长而显著增加（p小于0.01或p小于0.001）。衰老对淋巴细胞亚群的影响不太可能与SMON患者的这些免疫异常有关，但似乎SMON患者的免疫系统（B细胞或T细胞）在淋巴细胞亚群中被衰老以外的因素激活。
