将研究纳入抗逆转录病毒治疗项目的常规服务提供：从乌干达金贾一项比较艾滋病护理策略的整群随机试验中吸取的经验教训。

Integrating research into routine service delivery in an antiretroviral treatment programme: lessons learnt from a cluster randomized trial comparing strategies of HIV care in Jinja, Uganda.

作者信息

Jaffar Shabbar, Amuron Barbara, Birungi Josephine, Namara Geoffrey, Nabiryo Christine, Coutinho Alex, Grosskurth Heiner

机构信息

Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.

出版信息

Trop Med Int Health. 2008 Jun;13(6):795-800. doi: 10.1111/j.1365-3156.2008.02068.x. Epub 2008 Mar 18.

DOI:10.1111/j.1365-3156.2008.02068.x

PMID:18363588

Abstract

Trials integrated into normal health service delivery are designed to evaluate the effectiveness of interventions under real-life conditions. However, integrating research into service delivery creates many operational challenges and raises ethical dilemmas. Here we discuss the operational and ethical issues arising from such trials using the example of a cluster randomized trial evaluating two strategies of ART delivery in Jinja, south-east Uganda.

摘要

纳入常规卫生服务提供体系的试验旨在评估现实生活条件下干预措施的有效性。然而，将研究融入服务提供会带来诸多操作挑战并引发伦理困境。在此，我们以乌干达东南部金贾的一项整群随机试验为例，探讨此类试验中出现的操作和伦理问题，该试验评估了两种抗逆转录病毒治疗（ART）服务提供策略。