Azawi O I, Omran S N, Hadad J J
Department of Surgery and Obstetrics, College of Veterinary Medicine, University of Mosul, Mosul, Iraq.
Reprod Domest Anim. 2008 Oct;43(5):556-65. doi: 10.1111/j.1439-0531.2007.00952.x. Epub 2008 Mar 23.
The objectives of the present study were to determine the relationship between bacteriological findings, clinical signs and histopathological changes in postpartum metritis. Evaluation of the treatment efficiency of using systemic or intra-uterine infusion of antibiotics with some hormonal preparations for the treatment of postpartum metritis. Data were collected from 50 buffalo cows with history of calving of more than 1 month. All buffaloes were subjected to detailed clinical examination including external inspection, vaginoscopy and transrectal palpation of the cervix, uterus and ovaries. Swabs for bacteriology and biopsies for histopathology were collected from uterine lumen from each buffalo included in the present study. Bacteria identified using API systems following aerobic and anaerobic cultures. Vaginal mucus scored for character, odour and estimation of polymorphonuclear cells (PMNs). Treatment conducted using oxytetracycline in local intrauterine infusion or systemically with hormonal treatment including prostaglandin F2 alpha (PGF2 alpha) and oestradiol benzoate. Results revealed that the most predisposing factor for postpartum uterine infection was retained placenta and toxic puerperal metritis. The most prevalent bacteria in uterine lumen were Escherichia coli, Archanobacterium pyogenes, Bacteroides fragilis and Fusobacterium necrophorum the most prevalent bacteria in buffaloes with postpartum metritis. A. pyogenes and F. necrophorum were an important pathogens causing severe uterine inflammation as found in histopathological examinations. Buffaloes with postpartum metritis showed good clinical cure when oxytetracycline injected systemically with PGF2 alpha. Intrauterine infusion of oxytetracycline had no advantage for the treatment of uterine infection in buffalo cows with postpartum metritis. PGF2 alpha improved clinical cure of buffaloes with postpartum metritis.
本研究的目的是确定产后子宫炎的细菌学检查结果、临床症状和组织病理学变化之间的关系。评估全身或子宫内注射抗生素联合某些激素制剂治疗产后子宫炎的疗效。收集了50头产犊超过1个月的水牛的数据。所有水牛均接受了详细的临床检查，包括外部检查、阴道镜检查以及经直肠触诊子宫颈、子宫和卵巢。从本研究纳入的每头水牛的子宫腔内采集细菌学检查拭子和组织病理学检查活检样本。在需氧和厌氧培养后，使用API系统鉴定细菌。对阴道黏液的性状、气味和多形核白细胞（PMN）数量进行评分。采用土霉素进行局部子宫内注射或联合包括前列腺素F2α（PGF2α）和苯甲酸雌二醇在内的激素进行全身治疗。结果显示，产后子宫感染的最主要诱发因素是胎盘滞留和中毒性产褥期子宫炎。子宫腔内最常见的细菌是大肠杆菌、化脓隐秘杆菌、脆弱拟杆菌和坏死梭杆菌，这些是产后子宫炎水牛中最常见的细菌。组织病理学检查发现，化脓隐秘杆菌和坏死梭杆菌是导致严重子宫炎症的重要病原体。当土霉素与PGF2α联合全身注射时，产后子宫炎水牛显示出良好的临床治愈率。子宫内注射土霉素对治疗产后子宫炎的水牛子宫感染没有优势。PGF2α提高了产后子宫炎水牛的临床治愈率。
