Thomas C, Lippe W, Seinen W, Bloksma N
Research Institute of Toxicology, University of Utrecht, The Netherlands.
Int J Immunopharmacol. 1991;13(6):621-9. doi: 10.1016/0192-0561(91)90174-6.
Drugs that affect monoamine levels in the brain were screened for their potential to cause immunological changes in the popliteal lymph node (PLN) of mice after injection into the hind paw. The tricyclic antidepressant (TCA) drugs, imipramine and amitriptyline, and the serotonin reuptake blocker, zimeldine, induced a prominent PLN weight gain in C57BL/6 mice. Ketanserin and ritanserin appeared less effective while nomifensine, serotonin and the antigen, sheep erythrocytes, lacked significant activity. In BALB/c mice all agents induced an increase of PLN cell number, the TCA drugs and zimeldine appeared superior in this respect. Increased IgM as well as IgG production on a per cell basis was only induced by the TCA drugs, zimeldine and, especially, sheep erythrocytes. Data indicate that induction of PLN responses is not a general property of agents affecting monoamine levels. Structural, i.e. antigenic, characteristics of the drugs rather than their pharmacological properties are probably at play.
研究人员对影响大脑单胺水平的药物进行了筛选，观察它们注射到小鼠后爪后，在腘窝淋巴结（PLN）中引发免疫变化的可能性。三环类抗抑郁药（TCA）丙咪嗪和阿米替林，以及血清素再摄取阻滞剂齐美利定，可使C57BL/6小鼠的PLN重量显著增加。酮色林和利坦色林的效果似乎较差，而诺米芬辛、血清素和抗原羊红细胞则缺乏显著活性。在BALB/c小鼠中，所有药物均可诱导PLN细胞数量增加，在这方面TCA药物和齐美利定表现更优。仅TCA药物、齐美利定，尤其是羊红细胞，可诱导每细胞IgM和IgG产生增加。数据表明，诱导PLN反应并非影响单胺水平药物的普遍特性。药物的结构，即抗原特性，而非其药理特性可能起了作用。
