[Effect of indoleamine 2,3-dioxygenase on transplantation immunity].

OBJECTIVE

To review the research progress of possible mechanism of indoleamine 2, 3-dioxygenase (IDO) in immunological regulation and function of transplantation immunity.

METHODS

The advances in the IDO location, immunological regulatory mechanism and function of transplantation immunity were introduced based on the recent related literature.

RESULTS

IDO played an immunoregulatory role by locally depleting tryptophan in tissue microenvironment which resulted in immunosuppression of allogeneic T-cell proliferation. IDO cDNA was delivered to chromosome in interesting cells by gene transfection and stimulated to express, which was associated with a prolongation in allograft survival in vivo.

CONCLUSION

IDO offers a new way in transplantation immunity, and this provid novel method for elevating allograft survival rate.