Park Dong Soo, Chung Moon Kee, Chung Jae Il, Ahn Han Jong, Lee Eun Sik, Choi Han Yong, Yoon Duck Ki, Cheon Jun, Hong Sung Joon, Lee Young Goo, Yoon Sang Min, Kim Wun Jae, Kim Hyung Jin, Ryu Soo Bang, Ro Jae Y
The Korean Urological Oncology Society, Department of Urology, Bundang CHA Hospital, Pochon CHA University, College of Medicine, Sungnam, Korea.
Urol Oncol. 2008 Nov-Dec;26(6):590-4. doi: 10.1016/j.urolonc.2007.07.012. Epub 2008 Jan 14.
To investigate the presentation of germ cell tumors (GCT) in terms of histology and stage, to better clarify the epidemiology of this disease in eastern Asia.
Six hundred ninety-eight patients diagnosed with GCT between 1995 and 2004 were analyzed. Clinical parameters at the time of initial diagnosis were classified in terms of the American Joint Committee on Cancer (AJCC) tumor, nodes, metastasis staging (TNMS) system, the International Germ Cell Cancer Collaborative Classification (IGCCC), for high-risk stage I nonseminomatous GCT (NSGCT) of testis.
The anatomic distributions for the primary sites of the observed tumors were as follows: testis 471 cases (67%); central nervous system (CNS) 137 cases (20%); mediastinum 78 cases (11%), and retroperitoneum 12 cases (2%); 239 (51%) of 471 tumors with testicular primary were seminoma. High risk vs. non-high risk stage I NSGCT cases were 62 vs. 58. Of NSGCT of testis, 129 (58%), 73 (33%), and 21 (9%) of tumors presented with good, intermediate, and poor prognosis, respectively, based on IGCCC, whereas 231 (99%) patients were classified with a good prognosis and 3 (1%) with an intermediate prognosis amongst seminomas of testis; 193 (82%) cases presented as stage I testicular seminoma whereas 120 (54%) cases presented as stage I NSGCT.
Extragonadal primary GCTs are very common in Korean. Incidence of high risk NSGCT of testis with stage I disease was lower than in the Western report. NSGCT presents itself as a more aggressive form whereas seminoma is a very indolent tumor when compared with cases in Western countries.
从组织学和分期方面研究生殖细胞肿瘤（GCT）的表现，以更好地阐明东亚地区该疾病的流行病学情况。
对1995年至2004年间诊断为GCT的698例患者进行分析。根据美国癌症联合委员会（AJCC）肿瘤、淋巴结、转移分期（TNMS）系统以及国际生殖细胞癌协作组分类（IGCCC），对初诊时的临床参数进行分类，用于睾丸高危I期非精原细胞瘤（NSGCT）。
观察到的肿瘤原发部位的解剖分布如下：睾丸471例（67%）；中枢神经系统（CNS）137例（20%）；纵隔78例（11%），腹膜后12例（2%）；471例睾丸原发性肿瘤中239例（51%）为精原细胞瘤。高危与非高危I期NSGCT病例分别为62例和58例。根据IGCCC，睾丸NSGCT中，129例（58%）、73例（33%）和21例（9%）的肿瘤分别呈现良好、中等和不良预后，而睾丸精原细胞瘤中231例（99%）患者被分类为良好预后，3例（1%）为中等预后；193例（82%）病例表现为I期睾丸精原细胞瘤，而120例（54%）病例表现为I期NSGCT。
性腺外原发性GCT在韩国非常常见。睾丸高危I期疾病的NSGCT发病率低于西方报告。与西方国家的病例相比，NSGCT表现为更具侵袭性的形式，而精原细胞瘤是一种非常惰性的肿瘤。
