精原干细胞缺失的生态位：血管能指明方向吗？

The missing niche for spermatogonial stem cells: do blood vessels point the way?

作者信息

Shetty Gunapala, Meistrich Marvin L

机构信息

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

出版信息

Cell Stem Cell. 2007 Oct 11;1(4):361-3. doi: 10.1016/j.stem.2007.09.013.

DOI:10.1016/j.stem.2007.09.013

PMID:18371373

Abstract

Although spermatogonial stem cell niches have been defined in lower organisms, their definitive localization in mammalian seminiferous tubules has been elusive. In a recent Science paper, Yoshida et al. (2007) elegantly demonstrated a vascular and interstitial tissue-associated niche for undifferentiated spermatogonia in the mouse.

摘要

尽管在低等生物中已明确了精原干细胞龛的位置，但它们在哺乳动物生精小管中的确切定位一直难以捉摸。在最近发表于《科学》杂志的一篇论文中，吉田等人（2007年）巧妙地证明了小鼠中未分化精原细胞存在一个与血管和间质组织相关的龛。