细胞中的let-7是否决定干性？
Do cells let-7 determine stemness?
作者信息
Dröge Peter, Davey Curt A
机构信息
Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
出版信息
Cell Stem Cell. 2008 Jan 10;2(1):8-9. doi: 10.1016/j.stem.2007.12.003.
PMID:18371414
Abstract
During oncogenic transformation, microRNA levels of the translation-regulatory factor let-7 correlate inversely with expression of the HMGA2 oncoprotein. In a recent issue of Cell, Yu et al. (2007) now provide evidence that the let-7/HMGA2 linkage could be a signature of cancer stem cells in vivo, with broader implications for stem cell research.
摘要
在致癌转化过程中，翻译调节因子let-7的微小RNA水平与HMGA2癌蛋白的表达呈负相关。在最近一期的《细胞》杂志上，Yu等人（2007年）现在提供了证据，表明let-7/HMGA2联系可能是体内癌症干细胞的一个特征，对干细胞研究具有更广泛的意义。
Zotero 插件