肌肉卫星细胞自我更新与分化的微环境调控

Niche regulation of muscle satellite cell self-renewal and differentiation.

作者信息

Kuang Shihuan, Gillespie Mark A, Rudnicki Michael A

机构信息

The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.

出版信息

Cell Stem Cell. 2008 Jan 10;2(1):22-31. doi: 10.1016/j.stem.2007.12.012.

DOI:10.1016/j.stem.2007.12.012

PMID:18371418

Abstract

Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.

摘要

肌肉卫星细胞已被证明是一群异质性的定向肌源性祖细胞和未定向干细胞。这种由分化祖细胞和自我更新干细胞组成的层次结构确保了骨骼肌非凡的再生能力。最近的研究揭示了不对称分裂在卫星细胞维持中的作用，并为微环境对卫星细胞功能的调节提供了新的见解。深入了解卫星细胞以及肌肉中其他潜在干细胞的分子调控和细胞命运决定，对于基于干细胞治疗肌肉疾病的成功疗法至关重要。