Cossarizza A, Monti D, Bersani F, Scarfi M R, Zanotti M, Cadossi R, Franceschi C
Institute of General Pathology, University of Modena School of Medicine, Italy.
Aging (Milano). 1991 Sep;3(3):241-6. doi: 10.1007/BF03324014.
We previously reported that exposure of human mitogen-stimulated peripheral blood lymphocytes (PBL) to extremely low frequency pulsed electromagnetic fields (PEMFs) could restore the defective proliferative capability of PBL from aged subjects. The effects of exposure to PEMFs were studied in PBL from 25 patients with Down's syndrome (DS), a syndrome of premature aging characterized by precocious immune system derangement, including age-related defective PBL proliferative capability. PBL were stimulated with different doses of phytohemagglutinin, and cell proliferation was assessed by measuring the incorporation of tritiated thymidine. After PEMF-exposure, a significant increase in cell proliferation was observed in cells from DS children and young adults, but it was much more evident in PBL from relatively aged DS patients. The age-related effect of PEMFs on DS lymphocytes demonstrates that age must be considered a major variable when studies on DS are performed, and confirms that DS must be regarded as a syndrome of accelerated aging.
我们之前报道过，将人类有丝分裂原刺激的外周血淋巴细胞（PBL）暴露于极低频脉冲电磁场（PEMF）下，可以恢复老年受试者PBL有缺陷的增殖能力。对25名唐氏综合征（DS）患者的PBL进行了研究，以观察暴露于PEMF的影响。DS是一种早衰综合征，其特征为早熟的免疫系统紊乱，包括与年龄相关的PBL增殖能力缺陷。用不同剂量的植物血凝素刺激PBL，并通过测量氚标记胸腺嘧啶核苷的掺入来评估细胞增殖。暴露于PEMF后，在DS儿童和年轻成年人的细胞中观察到细胞增殖显著增加，但在相对年长的DS患者的PBL中更为明显。PEMF对DS淋巴细胞的年龄相关影响表明，在进行关于DS的研究时，年龄必须被视为一个主要变量，并证实DS必须被视为一种加速衰老的综合征。
