合成4'-修饰的去甲阿霉素以阐明4'-羟基对S-腺苷-L-高半胱氨酸水解酶抑制活性的影响。

Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase.

作者信息

Ando Takayuki, Kojima Kenji, Chahota Praveen, Kozaki Atsushi, Milind Nikalje D, Kitade Yukio

机构信息

Center for Emerging Infectious Diseases, Department of Biomolecular Science, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan.

出版信息

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2615-8. doi: 10.1016/j.bmcl.2008.03.029. Epub 2008 Mar 14.

DOI:10.1016/j.bmcl.2008.03.029

PMID:18374570

Abstract

4'-Modified noraristeromycin (NAM) analogs, 4'-sulfo-, 4'-sulfamoy, 4'-azido and 4'-amino-NAM, were systematically synthesized. The inhibitory activities of these analogs and related compounds against Plasmodium falciparum and human S-adenosyl-L-homocysteine hydrolase were investigated.

摘要

系统合成了4'-修饰的去甲分支杆菌素（NAM）类似物，即4'-磺基-NAM、4'-氨磺酰-NAM、4'-叠氮基-NAM和4'-氨基-NAM。研究了这些类似物及相关化合物对恶性疟原虫和人S-腺苷-L-高半胱氨酸水解酶的抑制活性。

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合成4'-修饰的去甲阿霉素以阐明4'-羟基对S-腺苷-L-高半胱氨酸水解酶抑制活性的影响。

Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase.

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合成4'-修饰的去甲阿霉素以阐明4'-羟基对S-腺苷-L-高半胱氨酸水解酶抑制活性的影响。

Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase.

作者信息

机构信息

出版信息

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