高血压糖尿病大鼠：链脲佐菌素治疗对成年自发性高血压大鼠和新生自发性高血压大鼠血压的不同影响。

Hypertensive diabetic rats: different effects of streptozotocin treatment on blood pressure in adult SHR and in neonatal SHR.

作者信息

Sato T, Nara Y, Kato Y, Yamori Y

机构信息

Department of Internal Medicine, Shimane Medical University, Izumo, Japan.

出版信息

Clin Exp Hypertens A. 1991;13(5):981-90. doi: 10.3109/10641969109042104.

DOI:10.3109/10641969109042104

PMID:1837761

Abstract

The effect of streptozotocin (STZ) treatment on blood pressure in adult spontaneously hypertensive rats (SHR) was compared with that in neonatal SHR. Three-month-old SHR were intravenously given 10, 30 or 50 mg/kg of STZ. When STZ was given in adult SHR, weight loss, overt hyperglycemia and the reduction of blood pressure occurred dose dependently. Two-day-old pups from SHR were subcutaneously injected with 100 mg/kg of STZ. Neonatal STZ treatment did not attenuate the development of hypertension in SHR. Since neonatally STZ-treated SHR develop mild diabetic symptom with hypertension and develop mild diabetic glomerulosclerosis, they are a good model for studying vascular complications or other disorder relating to the synergism between hypertension and diabetes mellitus.

摘要

将链脲佐菌素（STZ）治疗对成年自发性高血压大鼠（SHR）血压的影响与新生SHR进行了比较。给3个月大的SHR静脉注射10、30或50mg/kg的STZ。当给成年SHR注射STZ时，体重减轻、明显的高血糖和血压降低呈剂量依赖性发生。将SHR出生2天的幼崽皮下注射100mg/kg的STZ。新生期STZ治疗并未减轻SHR高血压的发展。由于新生期接受STZ治疗的SHR会出现伴有高血压的轻度糖尿病症状，并发展为轻度糖尿病性肾小球硬化，因此它们是研究与高血压和糖尿病之间协同作用相关的血管并发症或其他疾病的良好模型。