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使用自膨式金属支架缓解恶性结肠梗阻性病变:单中心经验

Palliation of obstructing malignant colonic lesions using self-expanding metal stents: a single-center experience.

作者信息

Shrivastava Vivek, Tariq Omar, Tiam ReeNee, Nyhsen Christiane, Marsh Ralph

机构信息

Department of Radiology, Freeman Hospital, Freeman Road, Newcastle Upon Tyne, NE7 7DN, UK.

出版信息

Cardiovasc Intervent Radiol. 2008 Sep-Oct;31(5):931-6. doi: 10.1007/s00270-008-9328-2. Epub 2008 Apr 1.

Abstract

To evaluate the efficacy, risks, and survival after palliative colorectal stenting at a single center, we conducted a retrospective review of consecutive patients who had colorectal self-expanding metal stents (SEMSs) inserted over an 8-year period (September 1998 to September 2006) to relieve an obstructing colorectal tumor. All patients either had proven distant metastases or were unfit for surgical decompression. A single interventional radiologist (R.M.) inserted the stents, which were either Memotherm or WallFlex. Ninety-one patients with a median age of 73 years had a colorectal stent inserted for palliation of an obstructing colorectal malignancy. Technical success was achieved in 81 of 91 (89%) patients, and clinical success in 80 of 81 (99%). At the time of analysis (December 2006), 13 of 91 (14.2%) patients were alive. The patients who died had a median survival of 59 days, IQR 17-181 days. Seven (7/81) patients suffered stent migration, which occurred 10.3 days (IQR, 5-14 days) after the procedure. Three patients (3/81) re-presented with intestinal obstruction secondary to tumor ingrowth and 10 (10.9%) patients suffered bowel perforation. Ten patients (10.9%) had two stents inserted coaxially and overlapping in one procedure. This was performed in cases where the stricture was too long to be easily crossed by a single stent. We conclude that colorectal SEMS is a safe and effective mode of treatment for the palliation of obstructing colorectal cancers, which avoids high-risk surgery.

摘要

为评估在单一中心进行姑息性结直肠支架置入术后的疗效、风险和生存率,我们对在8年期间(1998年9月至2006年9月)因结直肠肿瘤梗阻而置入结直肠自膨式金属支架(SEMS)的连续患者进行了回顾性研究。所有患者均已证实有远处转移或不适合手术减压。由一名介入放射科医生(R.M.)置入支架,支架类型为Memotherm或WallFlex。91例中位年龄为73岁的患者因结直肠恶性肿瘤梗阻而置入结直肠支架以缓解症状。91例患者中有81例(89%)技术成功,81例技术成功的患者中有80例(99%)临床成功。在分析时(2006年12月),91例患者中有13例(14.2%)存活。死亡患者的中位生存期为59天,四分位间距为17 - 181天。7例(7/81)患者发生支架移位,发生在术后10.3天(四分位间距,5 - 14天)。3例患者(3/81)因肿瘤长入导致肠梗阻复发,10例患者(10.9%)发生肠穿孔。10例患者(10.9%)在一次操作中同轴重叠置入了两个支架。在狭窄过长难以被单个支架轻松跨越的情况下进行了此项操作。我们得出结论,结直肠SEMS是缓解结直肠癌梗阻的一种安全有效的治疗方式,可避免高风险手术。

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