新型环氧化酶-2抑制剂GW637185X可预防1-甲基-4-苯基-1,2,3,6-四氢吡啶毒性。
The novel cyclooxygenase-2 inhibitor GW637185X protects against l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.
作者信息
Aguirre Jose A, Leo Giuseppina, Cueto Raquel, Andbjer Beth, Naylor Alan, Medhurst Andrew D, Agnati Luigi F, Fuxe Kjell
机构信息
Department of Human Physiology, School of Medicine, University of Malaga, Malaga, Spain.
出版信息
Neuroreport. 2008 Apr 16;19(6):657-60. doi: 10.1097/WNR.0b013e3282fb7898.
The possible neuroprotective role of a novel and highly selective cyclooxygenase-2 inhibitor GW637185X was studied in a model of acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced injury of nigrostriatal dopaminergic (DA) neurons in the mouse. Stereological and microdensitometrical analysis of nigral tyrosine hydroxylase-immunoreactive cell bodies and striatal tyrosine hydroxylase-immunoreactive terminals, respectively, showed that GW637185X exerted a full protection against MPTP-induced degeneration of the nigro-striatal pathway. In contrast to earlier studies, these findings demonstrate that acute inhibition of cyclooxygenase-2 can result in a full neuroprotective effect not only on nigral DA cell bodies, but also on striatal DA terminals in the mouse MPTP model.
在小鼠急性1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的黑质纹状体多巴胺能（DA）神经元损伤模型中，研究了一种新型高选择性环氧化酶-2抑制剂GW637185X可能的神经保护作用。分别对黑质酪氨酸羟化酶免疫反应性细胞体和纹状体酪氨酸羟化酶免疫反应性终末进行体视学和显微密度测定分析，结果显示GW637185X对MPTP诱导的黑质纹状体通路退变具有完全保护作用。与早期研究不同，这些发现表明，在小鼠MPTP模型中，急性抑制环氧化酶-2不仅可对黑质DA细胞体产生完全神经保护作用，还可对纹状体DA终末产生完全神经保护作用。
Zotero 插件