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视网膜水平细胞中由N-甲基-D-天冬氨酸受体引发的细胞内钙浓度变化。

Intracellular calcium concentration changes initiated by N-methyl-D-aspartic acid receptors in retinal horizontal cells.

作者信息

Wang Xu-Long, Jiang Xiao-Dong, Liang Pei-Ji

机构信息

Shanghai Jiao Tong University, Shanghai, China.

出版信息

Neuroreport. 2008 Apr 16;19(6):675-8. doi: 10.1097/WNR.0b013e3282fb7902.

Abstract

Intracellular calcium concentration changes initiated by N-methyl-D-aspartic acid receptors were studied in carp retinal horizontal cells. Fura-2 fluorescent calcium imaging showed that H1 subtype horizontal cells responded to exogenously applied N-methyl-D-aspartic acid with a transient intracellular free Ca(2+) ([Ca2+]i) increase that decayed to a sustained, but elevated level of [Ca(2+)]i. Contributions of different Ca(2+) flux pathways underlying the time course of this increase in [Ca(2+)]i were explored via experiment as well as via a computational model based on the biophysical properties of H1 cells. Intracellular calcium stores were suggested to play crucial role in the initial transient increase of [Ca(2+)]i.

摘要

在鲤鱼视网膜水平细胞中研究了由N-甲基-D-天冬氨酸受体引发的细胞内钙浓度变化。Fura-2荧光钙成像显示,H1亚型水平细胞对外源性施加的N-甲基-D-天冬氨酸有反应,细胞内游离Ca(2+)([Ca2+]i)短暂增加,随后衰减至持续但升高的[Ca(2+)]i水平。通过实验以及基于H1细胞生物物理特性的计算模型,探讨了[Ca(2+)]i增加的时间过程中不同Ca(2+)通量途径的作用。细胞内钙库被认为在[Ca(2+)]i的初始短暂增加中起关键作用。

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