激光辅助内镜下第三脑室造瘘术:202例患者的长期结果
Laser-assisted endoscopic third ventriculostomy: long-term results in a series of 202 patients.
作者信息
van Beijnum Janneke, Hanlo Patrick W, Fischer Kathelijn, Majidpour Mohsen M, Kortekaas Marlous F, Verdaasdonk Rudolf M, Vandertop W Peter
机构信息
Department of Neurosurgery, University Medical Center, Utrecht, The Netherlands.
出版信息
Neurosurgery. 2008 Feb;62(2):437-43; discussion 443-4. doi: 10.1227/01.neu.0000316011.13174.b1.
OBJECTIVE
Endoscopic third ventriculostomy is a well-known surgical option in the treatment of noncommunicating hydrocephalus. We studied complications and long-term success in 202 patients to demonstrate the safety and efficacy of laser-assisted endoscopic third ventriculostomy (LA-ETV) using a unique "black" fiber tip/diode laser combination for controlled tissue ablation.
METHODS
We studied 213 LA-ETVs, which were performed in 202 patients. Patients' ages ranged from 2 days to 83 years (mean age, 27 yr). The mean follow-up period for all patients was 2.7 years (range, 2 d to 12 yr). Hydrocephalus was caused by aqueductal stenosis in 65 patients, tumors in 67 patients, hemorrhages in 24 patients, myelomeningoceles in 20 patients, cysts in 15 patients, and other causes in 11 patients. The long-term effectiveness of LA-ETV was studied with Kaplan-Meier analysis.
RESULTS
Technically successful LA-ETVs were accomplished in 196 of the 202 patients (97%). The overall success rate for a functional LA-ETV was 68% at the 2-year follow-up evaluation. LA-ETV was more effective in patients aged 1 year and older (70% success rate) than in younger patients (59% success rate). Success rates were greater in patients with aqueductal stenosis or tumors as compared to other etiologies. Complications occurred in 22 procedures (10.3%). Only one patient (0.5%) experienced a major complication. No surgical mortalities or laser-related complications occurred.
CONCLUSION
This study demonstrates that LA-ETV is a safe and effective procedure that is comparable to other techniques for ETV. LA-ETV is most effective in patients aged 1 year and older and in patients with aqueductal stenosis and tumors, with a low major complication rate.
目的
内镜下第三脑室造瘘术是治疗非交通性脑积水的一种广为人知的手术选择。我们研究了202例患者的并发症及长期手术成功率,以证明使用独特的“黑色”光纤尖端/二极管激光组合进行可控组织消融的激光辅助内镜下第三脑室造瘘术(LA - ETV)的安全性和有效性。
方法
我们研究了在202例患者中进行的213次LA - ETV手术。患者年龄从2天至83岁不等(平均年龄27岁)。所有患者的平均随访期为2.7年(范围2天至12年)。脑积水的病因包括中脑导水管狭窄65例、肿瘤67例、出血24例、脊髓脊膜膨出20例、囊肿15例以及其他原因11例。采用Kaplan - Meier分析研究LA - ETV的长期有效性。
结果
202例患者中有196例(97%)的LA - ETV手术在技术上成功。在2年的随访评估中,功能性LA - ETV的总体成功率为68%。LA - ETV在1岁及以上患者中(成功率70%)比年轻患者(成功率59%)更有效。与其他病因相比,中脑导水管狭窄或肿瘤患者的成功率更高。22例手术(10.3%)发生了并发症。仅1例患者(0.5%)出现严重并发症。未发生手术死亡或与激光相关的并发症。
结论
本研究表明,LA - ETV是一种安全有效的手术,与其他ETV技术相当。LA - ETV在1岁及以上患者以及中脑导水管狭窄和肿瘤患者中最有效,严重并发症发生率低。