鼻窦未分化癌的管理

Management of sinonasal undifferentiated carcinoma.

作者信息

Tanzler Emily D, Morris Christopher G, Orlando Christine A, Werning John W, Mendenhall William M

机构信息

Department of Radiation Oncology, University of Florida, College of Medicine, Gainesville, Florida, USA.

出版信息

Head Neck. 2008 May;30(5):595-9. doi: 10.1002/hed.20748.

DOI:10.1002/hed.20748

PMID:18383526

Abstract

BACKGROUND

Our aim was to report the outcomes of treatment for sinonasal undifferentiated carcinoma (SNUC).

METHODS

Between September 1992 and October 2005, 15 patients were treated with curative intent with surgery (n=1), surgery and adjuvant radiotherapy (n=9), and definitive radiotherapy (RT) (n=5). Follow-up ranged from 11 to 151 months (median, 30); follow-up on living patients ranged from 12 to 151 months (median, 22). No patient was lost to follow-up.

RESULTS

Seven patients (47%) developed a recurrence from 3 to 50 months (median, 9) after treatment. The 3-year outcomes were: local control, 78%; locoregional control, 65%; distant metastasis-free survival, 82%; cause-specific survival, 77%, and survival, 67%. The local control rates versus treatment modality were: surgery, 0/1 (0%); surgery and postoperative RT, 7/7 (100%); preoperative RT and surgery, 2/2 (100%); and definitive RT, 2/5 (40%). One patient (7%) treated with surgery and postoperative RT sustained a fatal complication.

CONCLUSIONS

Combined surgery and adjuvant RT likely offer the best chance of cure compared with either modality alone. The impact of adjuvant chemotherapy is unclear.

摘要

背景

我们的目的是报告鼻窦未分化癌（SNUC）的治疗结果。

方法

1992年9月至2005年10月期间，15例患者接受了旨在治愈的治疗，其中手术治疗1例，手术联合辅助放疗9例，根治性放疗5例。随访时间为11至151个月（中位数为30个月）；存活患者的随访时间为12至151个月（中位数为22个月）。没有患者失访。

结果

7例患者（47%）在治疗后3至50个月（中位数为9个月）出现复发。3年的治疗结果为：局部控制率78%；区域控制率65%；无远处转移生存率82%；病因特异性生存率77%，总生存率67%。不同治疗方式的局部控制率分别为：手术治疗，0/1（0%）；手术联合术后放疗，7/7（100%）；术前放疗联合手术，2/2（100%）；根治性放疗，2/5（40%）。1例接受手术联合术后放疗的患者出现致命并发症（7%）。