皮肤黑色素瘤患者前哨淋巴结术中印片触摸细胞学检查的准确率为94%。
94% accuracy of intraoperative imprint touch cytology of sentinel nodes in skin melanoma patients.
作者信息
Nejc Dariusz, Pasz-Walczak Grazyna, Piekarski Janusz, Pluta Piotr, Sek Piotr, Bilski Adam, Durczynski Adam, Berner Andrzej, Jastrzebski Tomasz, Jeziorski Arkadiusz
机构信息
Department of Surgical Oncology, Medical University of Lodz, Poland.
出版信息
Anticancer Res. 2008 Jan-Feb;28(1B):465-9.
UNLABELLED
The aim of the present study was to assess whether the reliability of imprint touch cytology (ITC) of sentinel nodes in skin melanoma patients allows intraoperative decisions regarding simultaneous radical lymphadenectomy to be made.
PATIENTS AND METHODS
The results of ITC of sentinel nodes were compared with the results of standard histopathological and immunohistochemical examinations.
RESULTS
A total of 148 sentinel nodes were identified in 98 lymph node groups in 85 skin melanoma patients. ITC revealed the presence of metastases in 7 out of 16 melanoma-positive sentinel nodes (sensitivity, 43.7%). There were no false-positive results of ITC of sentinel nodes (specificity, 100%). The negative predictive value of ITC was 93.6%, the positive predictive value was 100%, and the accuracy of the method was 93.9%.
CONCLUSION
ITC of sentinel nodes is a reliable method. There was no risk of overtreatment due to false-positive results of sentinel node ITC in our study. High accuracy of the method warrants its clinical use.
未标注
本研究的目的是评估皮肤黑色素瘤患者前哨淋巴结印片触摸细胞学检查（ITC）的可靠性是否能使术中做出关于同步根治性淋巴结清扫术的决策。
患者和方法
将前哨淋巴结ITC的结果与标准组织病理学和免疫组织化学检查的结果进行比较。
结果
85例皮肤黑色素瘤患者的98个淋巴结组中共识别出148个前哨淋巴结。ITC在16个黑色素瘤阳性前哨淋巴结中的7个中显示有转移（敏感性，43.7%）。前哨淋巴结ITC没有假阳性结果（特异性，100%）。ITC的阴性预测值为93.6%，阳性预测值为100%，该方法的准确性为93.9%。
结论
前哨淋巴结ITC是一种可靠的方法。在我们的研究中，没有因前哨淋巴结ITC假阳性结果导致过度治疗的风险。该方法的高准确性保证了其临床应用。
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