Kovács Márta, Pák Péter, Uhlyarik Andrea, Pák Gábor, Török Attila, Gervain Judit, Fehér János
Vaszary Kolos Kórház, II. Belgyógyászati Osztály, Esztergom.
Orv Hetil. 2008 Apr 13;149(15):697-701. doi: 10.1556/OH.2008.28350.
Small intestinal stromal tumors account for approximately 35% of all gastrointestinal stromal tumors. Gastrointestinal bleeding is considered as one of the main clinical symptoms for SISTs. Capsule endoscopy has brought revolution in small bowel diagnostics, as it is considered the best method of visualisation of the entire small intestine. Besides, it is well tolerated by patients and is accompanied by a low number of complications. It is also indicated as the first diagnostic method in gastrointestinal bleeding of obscure origin, following negative upper endoscopy and colonoscopy.
2 patients (a male and a female, aged 58 and 69, respectively) presented with obscure gastrointestinal bleeding have been examined by capsule endoscopy after negative upper endoscopy and colonoscopy. Videorecords have been assessed in both cases by two independent experts. The capsule reached the Bauchin-valve in both cases during the 8 hours of the testing time and the entire small bowel was clearly visible. - Based on the capsule endoscopic images, for one of the two cases a tumor has been reported as the background of the small intestinal bleeding. In the other case we could mark the location of the bleeding, while we were unable to ascertain the type of the actively bleeding lesion during the test. In order to determine the accurate bleeding source double-balloon enteroscopy was performed in the second case. After surgery the histological and immunohistochemical tests have justified the presence of spindle cell GISTs. Taking into consideration the Fletcher-classification, for the tumor size and the mitotic index, both cases can be classified as a GIST of low malignant potential.
An early diagnosis and application of a definitive therapy become possible by using capsule endoscopy, therefore the chance of survival of the patients might be increased.
小肠间质瘤约占所有胃肠道间质瘤的35%。胃肠道出血被认为是小肠间质瘤的主要临床症状之一。胶囊内镜给小肠诊断带来了变革,因为它被认为是观察整个小肠的最佳方法。此外,患者对其耐受性良好,并发症较少。在不明原因的胃肠道出血中,经上消化道内镜和结肠镜检查阴性后,它也被作为首选诊断方法。
2例不明原因胃肠道出血患者(1例男性,1例女性,年龄分别为58岁和69岁),经上消化道内镜和结肠镜检查阴性后,接受了胶囊内镜检查。两位独立专家对两例患者的视频记录进行了评估。在8小时的检查时间内,两例患者的胶囊均到达回盲瓣,整个小肠清晰可见。——根据胶囊内镜图像,两例中的一例报告有肿瘤是小肠出血的原因。另一例中,我们能够标记出血部位,但在检查期间无法确定活动性出血病变的类型。为了确定准确的出血源,第二例患者进行了双气囊小肠镜检查。手术后,组织学和免疫组化检查证实存在梭形细胞胃肠道间质瘤。根据弗莱彻分类法,考虑到肿瘤大小和有丝分裂指数,两例均可归类为低恶性潜能的胃肠道间质瘤。
使用胶囊内镜可实现早期诊断并应用确定性治疗,因此可能提高患者的生存率。