Thompson John F, Kam Peter C A
Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Int J Hyperthermia. 2008 May;24(3):219-25. doi: 10.1080/02656730701827565.
Recurrent disease confined to a limb is a frequently encountered clinical problem in patients with melanoma. Regional chemotherapy by isolated limb perfusion (ILP) provides effective treatment but is invasive, complex and costly. Isolated limb infusion (ILI) is a simple yet effective alternative to ILP.
ILI involves drug administration into a limb via percutaneously inserted catheters after vascular isolation of the limb has been achieved with a tourniquet. The infused drug is circulated for 30 minutes via a simple extracorporeal circuit incorporating a heater (to produce mild hyperthermia).
Limb tumour remission rates are similar to those achieved by conventional ILP. ILI is well tolerated, and elderly patients and those with major medical co-morbidities and serious peripheral vascular problems can be treated.
ILI with mild hyperthermia is an established alternative to hyperthermic ILP for patients with recurrent limb melanoma. It can also be used for patients with soft tissue sarcomas and a variety of serious, chronic dermatological conditions.
黑色素瘤患者中，局限于肢体的复发性疾病是一个常见的临床问题。通过隔离肢体灌注（ILP）进行区域化疗可提供有效的治疗，但具有侵入性、操作复杂且成本高昂。隔离肢体输注（ILI）是一种简单而有效的替代ILP的方法。
ILI是在使用止血带实现肢体血管隔离后，通过经皮插入的导管将药物注入肢体。注入的药物通过一个包含加热器（以产生轻度热疗）的简单体外循环循环30分钟。
肢体肿瘤缓解率与传统ILP相似。ILI耐受性良好，老年患者以及患有严重内科合并症和严重外周血管问题的患者均可接受治疗。
对于复发性肢体黑色素瘤患者，轻度热疗的ILI是热疗性ILP的既定替代方法。它也可用于软组织肉瘤患者以及各种严重的慢性皮肤病患者。
