RanBP2：一种对拓扑异构酶II、小泛素样修饰蛋白及着丝粒有新作用方式的肿瘤抑制因子。

RanBP2: a tumor suppressor with a new twist on TopoII, SUMO, and centromeres.

作者信息

Navarro Michelle S, Bachant Jeff

机构信息

Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.

出版信息

Cancer Cell. 2008 Apr;13(4):293-5. doi: 10.1016/j.ccr.2008.03.011.

DOI:10.1016/j.ccr.2008.03.011

PMID:18394551

Abstract

In vertebrate cells, the small ubiquitin-like modifier SUMO plays a poorly defined role in targeting DNA topoisomerase II (TopoII) to centromeres (CENs) during mitosis, presumably to facilitate the untangling of sister chromatids as cells transition into anaphase. A new study by Dawlaty in the April 4 issue of Cell identifies the nucleoporin RanBP2 as a novel tumor suppressor that acts as a SUMO ligase for TopoII. Analysis of this interaction reveals TopoII recruitment to CENs is likely to play an important role in preventing chromosome segregation errors that lead to cancer.

摘要

在脊椎动物细胞中，小泛素样修饰物SUMO在有丝分裂期间将DNA拓扑异构酶II（TopoII）靶向着丝粒（CENs）的过程中所起的作用尚不明确，推测是为了在细胞进入后期时促进姐妹染色单体的解缠。Dawlaty在4月4日那期《细胞》杂志上发表的一项新研究确定核孔蛋白RanBP2是一种新型肿瘤抑制因子，它作为TopoII的SUMO连接酶发挥作用。对这种相互作用的分析表明，TopoII募集到CENs可能在预防导致癌症的染色体分离错误方面发挥重要作用。