Newman Mary B, Bakay Roy A E
Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois 60612, USA.
Neurotherapeutics. 2008 Apr;5(2):237-51. doi: 10.1016/j.nurt.2008.02.004.
The loss of dopaminergic neurons of the substantia nigra is the pathological hallmark characteristic of Parkinson's disease (PD). The strategy of replacing these degenerating neurons with other cells that produce dopamine has been the main approach in the cell transplantation field for PD research. The isolation, differentiation, and long-term cultivation of human embryonic stem cells and the therapeutic research discovery made in relation to the beneficial properties of neurotrophic and neural growth factors has advanced the transplantation field beyond dopamine-producing cells. The present review addresses recent advances in human embryonic stem cell experimentation in relation to treating PD, as well as cell transplantation techniques in conjunction with alternative therapeutics.
黑质多巴胺能神经元的丧失是帕金森病(PD)的病理标志性特征。用其他产生多巴胺的细胞替代这些退化神经元的策略一直是帕金森病研究细胞移植领域的主要方法。人类胚胎干细胞的分离、分化和长期培养,以及与神经营养因子和神经生长因子有益特性相关的治疗研究发现,推动了移植领域超越产多巴胺细胞的范畴。本综述阐述了人类胚胎干细胞治疗帕金森病实验的最新进展,以及与替代疗法相结合的细胞移植技术。