Denis D, Pommier S, Coste R, Fogliarini C, Benso C, Cornand E
Service d'Ophtalmologie, Centre Hospitalo-Universitaire Nord, Marseille.
J Fr Ophtalmol. 2008 Feb;31(2):173-9. doi: 10.1016/s0181-5512(08)70350-4.
To assess the outcome of deep sclerectomy surgery with intraoperative antimitotic application in children with primary and secondary congenital glaucomas.
Thirty-seven eyes of 22 children aged from 1 day to 14 years were included in this study; 30 eyes had primary congenital glaucoma and were divided into two groups according to the management delay. Eighteen eyes were managed early (group 1) and 12 eyes were diagnosed late (group 2). Finally, seven eyes had a more complex dysgenic glaucoma (group 3). All the eyes had a deep sclerectomy with antimitotic intraoperative application (5 FU). Pre- and postoperative intraocular pressures, success rate, preoperative corneal transparency, corneal diameter, and surgical complications were assessed. Total success was defined by final postoperative intraocular pressure lower than 16 mmHG without combined medical treatment; partial success was defined by lower than 16 mmHG with a combined medical treatment.
The mean follow-up was 38.2 months. Total success was 34% and partial was 82%: 56% and 89%, respectively, for group 1, 33% and 100% for group 2, and 14% and 57% for group 3. No severe complications occurred after surgery.
The probability of success was significantly lower for secondary congenital glaucomas and for primary congenital glaucomas with late management. Management delay and the type of glaucoma seem to be capital in the prognosis of high intraocular pressure. Deep sclerectomy with antimitotic application (5 FU) is a good alternative to trabeculectomy in primary glaucomas.
评估在原发性和继发性先天性青光眼患儿中,术中应用抗有丝分裂药物的深层巩膜切除术的手术效果。
本研究纳入了22名年龄从1天至14岁儿童的37只眼;30只眼患有原发性先天性青光眼,并根据治疗延迟情况分为两组。18只眼为早期治疗组(第1组),12只眼为晚期诊断组(第2组)。最后,7只眼患有更复杂的发育异常性青光眼(第3组)。所有眼睛均接受了术中应用抗有丝分裂药物(5-氟尿嘧啶)的深层巩膜切除术。评估术前和术后眼压﹑成功率﹑术前角膜透明度﹑角膜直径及手术并发症。总成功定义为术后最终眼压低于16 mmHg且无需联合药物治疗;部分成功定义为联合药物治疗后眼压低于16 mmHg。
平均随访38.2个月。总成功率为34%,部分成功率为82%:第1组分别为56%和89%,第2组为33%和100%,第3组为14%和57%。术后未发生严重并发症。
继发性先天性青光眼和治疗延迟的原发性先天性青光眼的成功概率显著较低。治疗延迟和青光眼类型似乎是高眼压预后的关键因素。术中应用抗有丝分裂药物(5-氟尿嘧啶)的深层巩膜切除术是原发性青光眼小梁切除术的良好替代方法。