Kruit W H J
Erasmus MC-Daniel den Hoed Oncologisch Centrum, afd. Interne Oncologie, Postbus 5201, 3075 EA Rotterdam.
Ned Tijdschr Geneeskd. 2008 Mar 8;152(10):574-6.
The sentinel lymph node procedure provides prognostic information for patients with cutaneous melanoma, but its therapeutic implications were unclear until now. The international multicentre selective lymphadenectomy trial has shown that sentinel lymph node biopsy confers no survival benefit for patients with cutaneous melanoma. The presence of melanoma cells in a sentinel lymph node, however, has prognostic value. Therefore, the Dutch Melanoma Working Group recommends discussing this procedure with all patients with melanoma of Breslow thickness 1.2-3.5 mm. There is no evidence to suggest that the sentinel lymph node procedure is beneficial when the Breslow thickness is less than 1.2 mm or greater than 3.5 mm.
前哨淋巴结活检可为皮肤黑色素瘤患者提供预后信息,但直到现在其治疗意义仍不明确。国际多中心选择性淋巴结清扫试验表明,前哨淋巴结活检对皮肤黑色素瘤患者并无生存益处。然而,前哨淋巴结中存在黑色素瘤细胞具有预后价值。因此,荷兰黑色素瘤工作组建议与所有Breslow厚度为1.2 - 3.5 mm的黑色素瘤患者讨论这一手术。没有证据表明当Breslow厚度小于1.2 mm或大于3.5 mm时,前哨淋巴结手术有益。