Vakifahmetoglu H, Olsson M, Zhivotovsky B
Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Cell Death Differ. 2008 Jul;15(7):1153-62. doi: 10.1038/cdd.2008.47. Epub 2008 Apr 11.
Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from premature or inappropriate entry of cells into mitosis and can be caused by chemical or physical stresses. Whereas it initially was depicted as the main form of cell death induced by ionizing radiation, it is today known to be triggered also by treatment with agents influencing the stability of microtubule, various anticancer drugs and mitotic failure caused by defective cell cycle checkpoints. Although various descriptions explaining MC exist, there is still no general accepted definition of this phenomenon. Here, we present evidences indicating that death-associated MC is not a separate mode of cell death, rather a process ('prestage') preceding cell death, which can occur through necrosis or apoptosis. The final outcome of MC depends on the molecular profile of the cell.
有丝分裂灾难（MC）长期以来一直被视为一种细胞死亡模式，它源于细胞过早或不恰当地进入有丝分裂，可由化学或物理应激引发。虽然它最初被描述为电离辐射诱导的主要细胞死亡形式，但如今已知它也可由影响微管稳定性的药物处理、各种抗癌药物以及细胞周期检查点缺陷导致的有丝分裂失败所触发。尽管存在各种解释MC的描述，但对于这一现象仍没有普遍接受的定义。在此，我们提供证据表明，与死亡相关的MC并非一种独立的细胞死亡模式，而是细胞死亡之前的一个过程（“前期阶段”），它可通过坏死或凋亡发生。MC的最终结果取决于细胞的分子特征。
