Wehling M
Innenstadt Medical Clinic, University of Munich, Munich, Germany.
Trends Endocrinol Metab. 1994 Oct;5(8):347-53. doi: 10.1016/1043-2760(94)90165-1.
The genomic theory of steroid action has dominated research in the field over the past 4 decades. Despite early observations on rapid steroid effects being clearly incompatible with this theory, only recently has immediate steroid action been more widely recognized and is summarized here, with the emphasis on aldosterone. Further evidence for nongenomic steroid effects is also gathered rapidly for various groups of other steroids, such as neurosteroids, vitamin D(3), and estrogens.
在过去的40年里,类固醇作用的基因组理论一直主导着该领域的研究。尽管早期关于类固醇快速作用的观察结果显然与该理论不相容,但直到最近,类固醇的即时作用才得到更广泛的认可,本文对此进行了总结,重点是醛固酮。对于其他各类类固醇,如神经类固醇、维生素D(3)和雌激素,非基因组类固醇作用的进一步证据也在迅速积累。