Krystal Andrew D, Goforth Harold W, Roth Thomas
Duke Insomnia and Sleep Research Program, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Int Clin Psychopharmacol. 2008 May;23(3):150-60. doi: 10.1097/YIC.0b013e3282f39703.
Schizophrenia is often accompanied by sleep problems. Evidence exists that these sleep difficulties have significant effects on individuals with this disorder. The mainstay of treatment for this condition is the administration of medications that have effects on neurotransmitter systems, which play an important role in sleep-wake function, including histamine, acetylcholine, serotonin, norepinephrine and dopamine. Little systematic attention, however, has been paid to how the sleep effects of these agents might play a role in the course of treatment, function and quality of life of schizophrenia patients. Schizophrenia medications can improve sleep problems and reverse the sleep architectural derangements that are common among patients with schizophrenia and, therefore, have the potential to improve the quality of life and functional capacity of the patient. Conversely, some sleep-wake effects of these medications can impair patient function and quality of life. In this study, we review the effects of schizophrenia medications and discuss their relevance to optimizing the clinical treatment of people with schizophrenia with regard to sleep-wake function.
精神分裂症常伴有睡眠问题。有证据表明，这些睡眠困难对患有这种疾病的个体有重大影响。这种病症的主要治疗方法是使用对神经递质系统有作用的药物，神经递质系统在睡眠-觉醒功能中起重要作用，包括组胺、乙酰胆碱、血清素、去甲肾上腺素和多巴胺。然而，对于这些药物的睡眠效应如何在精神分裂症患者的治疗过程、功能和生活质量中发挥作用，却很少有系统的关注。治疗精神分裂症的药物可以改善睡眠问题，并扭转精神分裂症患者中常见的睡眠结构紊乱，因此有潜力提高患者的生活质量和功能能力。相反，这些药物的一些睡眠-觉醒效应可能会损害患者的功能和生活质量。在本研究中，我们回顾了治疗精神分裂症药物的效应，并讨论它们在优化精神分裂症患者睡眠-觉醒功能的临床治疗方面的相关性。
