Izumi Takeshi, Inoue Takeshi, Kato Akiko, Kitaichi Yuji, Nakagawa Shin, Koyama Tsukasa
Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060-8638, Japan.
Pharmacol Biochem Behav. 2008 Sep;90(3):297-304. doi: 10.1016/j.pbb.2008.02.023. Epub 2008 Mar 8.
The purpose of the present study was to characterize functional changes in the amygdala that accompany the extinction of context-dependent conditioned fear stress in a rat, an animal model of anxiety. Specifically, the effect of extinction of conditioned fear-induced cyclic AMP responsive element-binding protein (CREB) phosphorylation in the amygdala was investigated using immunohistochemistry. Experiments demonstrated that CREB phosphorylation in the basal nucleus of the amygdala decreased with the extinction of context-dependent conditioned fear-induced freezing behavior. These data suggest that the basal nucleus of the amygdala plays an essential role in the expression of context-dependent conditioned fear. Further, this is the first study to demonstrate that CREB phosphorylation in the basal nucleus of the amygdala changes in parallel with the extinction of context-dependent conditioned fear.
本研究的目的是描述杏仁核中的功能变化，这些变化伴随着焦虑动物模型——大鼠中与情境相关的条件性恐惧应激的消退。具体而言，使用免疫组织化学研究了条件性恐惧诱导的杏仁核中环磷酸腺苷反应元件结合蛋白（CREB）磷酸化消退的影响。实验表明，随着与情境相关的条件性恐惧诱导的僵住行为的消退，杏仁核基底核中的CREB磷酸化减少。这些数据表明，杏仁核基底核在与情境相关的条件性恐惧的表达中起重要作用。此外，这是第一项证明杏仁核基底核中的CREB磷酸化与与情境相关的条件性恐惧的消退平行变化的研究。
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