两亲性药物通过脂质双层对离子通道功能的调节 - Suppr

Suppr

超能文献

Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs.

作者信息

Lundbaek Jens A

机构信息

Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA.

出版信息

J Gen Physiol. 2008 May;131(5):421-9. doi: 10.1085/jgp.200709948. Epub 2008 Apr 14.

DOI:10.1085/jgp.200709948

PMID:18411332

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2346573/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcc/2346573/35590f222bc1/jgp1310421f01.jpg

相似文献

Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs.

J Gen Physiol. 2008 May;131(5):421-9. doi: 10.1085/jgp.200709948. Epub 2008 Apr 14.

Amphiphile regulation of ion channel function by changes in the bilayer spring constant.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15427-30. doi: 10.1073/pnas.1007455107. Epub 2010 Aug 16.

Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based and Assays.

J Med Chem. 2020 Oct 22;63(20):11809-11818. doi: 10.1021/acs.jmedchem.0c00958. Epub 2020 Oct 1.

Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics.

Biochemistry. 2003 Nov 25;42(46):13646-58. doi: 10.1021/bi034887y.

Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12717-22. doi: 10.1073/pnas.1103192108. Epub 2011 Jul 18.

Ion channel stability of Gramicidin A in lipid bilayers: effect of hydrophobic mismatch.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):328-38. doi: 10.1016/j.bbamem.2013.10.005. Epub 2013 Oct 11.

Single molecule methods for monitoring changes in bilayer elastic properties.

J Vis Exp. 2008 Nov 3(21):1032. doi: 10.3791/1032.

The gramicidin ion channel: a model membrane protein.

Biochim Biophys Acta. 2007 Sep;1768(9):2011-25. doi: 10.1016/j.bbamem.2007.05.011. Epub 2007 May 18.

Hydrophobic coupling of lipid bilayer energetics to channel function.

J Gen Physiol. 2003 May;121(5):477-93. doi: 10.1085/jgp.200308797.

Lipid bilayer electrostatic energy, curvature stress, and assembly of gramicidin channels.

Biochemistry. 1997 May 13;36(19):5695-701. doi: 10.1021/bi9619841.

引用本文的文献

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening.

Membranes (Basel). 2022 Sep 28;12(10):954. doi: 10.3390/membranes12100954.

Discovery of agonist-antagonist pairs for the modulation of Ca and voltage-gated K channels of large conductance that contain beta1 subunits.

Bioorg Med Chem. 2022 Aug 15;68:116876. doi: 10.1016/j.bmc.2022.116876. Epub 2022 Jun 13.

The interaction of steroids with phospholipid bilayers and membranes.

Biophys Rev. 2021 Dec 2;14(1):163-179. doi: 10.1007/s12551-021-00918-2. eCollection 2022 Feb.

Quantitative Analysis of the Membrane Affinity of Local Anesthetics Using a Model Cell Membrane.

Membranes (Basel). 2021 Jul 30;11(8):579. doi: 10.3390/membranes11080579.

BK channel-forming slo1 proteins mediate the brain artery constriction evoked by the neurosteroid pregnenolone.

Neuropharmacology. 2021 Jul 1;192:108603. doi: 10.1016/j.neuropharm.2021.108603. Epub 2021 May 21.

Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations.

Biophys J. 2018 Mar 27;114(6):1321-1335. doi: 10.1016/j.bpj.2018.01.028.

β-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent.

Biophys J. 2017 Sep 5;113(5):1080-1092. doi: 10.1016/j.bpj.2017.07.010.

Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity.

Molecules. 2017 Aug 18;22(8):1369. doi: 10.3390/molecules22081369.

The Water Permeability and Pore Entrance Structure of Aquaporin-4 Depend on Lipid Bilayer Thickness.

Biophys J. 2016 Jul 12;111(1):90-9. doi: 10.1016/j.bpj.2016.05.039.

The Influence of Lipid Bilayer Physicochemical Properties on Gramicidin A Conformer Preferences.

Biophys J. 2016 Apr 26;110(8):1826-1835. doi: 10.1016/j.bpj.2016.03.020.

本文引用的文献

Regulation of membrane protein function by lipid bilayer elasticity-a single molecule technology to measure the bilayer properties experienced by an embedded protein.

J Phys Condens Matter. 2006 Jul 19;18(28):S1305-44. doi: 10.1088/0953-8984/18/28/S13. Epub 2006 Jun 28.

The influence of drug-like concepts on decision-making in medicinal chemistry.

Nat Rev Drug Discov. 2007 Nov;6(11):881-90. doi: 10.1038/nrd2445.

Single-molecule methods for monitoring changes in bilayer elastic properties.

Methods Mol Biol. 2007;400:543-70. doi: 10.1007/978-1-59745-519-0_37.

Docosahexaenoic acid alters bilayer elastic properties.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9638-43. doi: 10.1073/pnas.0701015104. Epub 2007 May 29.

Bilayer thickness and membrane protein function: an energetic perspective.

Annu Rev Biophys Biomol Struct. 2007;36:107-30. doi: 10.1146/annurev.biophys.36.040306.132643.

GABA(A) receptor function is regulated by lipid bilayer elasticity.

Biochemistry. 2006 Oct 31;45(43):13118-29. doi: 10.1021/bi060734+.

TRPV1 is a novel target for omega-3 polyunsaturated fatty acids.

J Physiol. 2007 Jan 15;578(Pt 2):397-411. doi: 10.1113/jphysiol.2006.121988. Epub 2006 Oct 12.

The receptor concept: pharmacology's big idea.

Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S9-16. doi: 10.1038/sj.bjp.0706457.

Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity.

Mol Pharmacol. 2005 Sep;68(3):680-9. doi: 10.1124/mol.105.013573. Epub 2005 Jun 20.

Lysophospholipid receptors: signaling and biology.

Annu Rev Biochem. 2004;73:321-54. doi: 10.1146/annurev.biochem.73.011303.073731.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

相似文献

Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs.

J Gen Physiol. 2008 May;131(5):421-9. doi: 10.1085/jgp.200709948. Epub 2008 Apr 14.

Amphiphile regulation of ion channel function by changes in the bilayer spring constant.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15427-30. doi: 10.1073/pnas.1007455107. Epub 2010 Aug 16.

Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based and Assays.

J Med Chem. 2020 Oct 22;63(20):11809-11818. doi: 10.1021/acs.jmedchem.0c00958. Epub 2020 Oct 1.

Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics.

Biochemistry. 2003 Nov 25;42(46):13646-58. doi: 10.1021/bi034887y.

Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12717-22. doi: 10.1073/pnas.1103192108. Epub 2011 Jul 18.

Ion channel stability of Gramicidin A in lipid bilayers: effect of hydrophobic mismatch.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):328-38. doi: 10.1016/j.bbamem.2013.10.005. Epub 2013 Oct 11.

Single molecule methods for monitoring changes in bilayer elastic properties.

J Vis Exp. 2008 Nov 3(21):1032. doi: 10.3791/1032.

The gramicidin ion channel: a model membrane protein.

Biochim Biophys Acta. 2007 Sep;1768(9):2011-25. doi: 10.1016/j.bbamem.2007.05.011. Epub 2007 May 18.

Hydrophobic coupling of lipid bilayer energetics to channel function.

J Gen Physiol. 2003 May;121(5):477-93. doi: 10.1085/jgp.200308797.

Lipid bilayer electrostatic energy, curvature stress, and assembly of gramicidin channels.

Biochemistry. 1997 May 13;36(19):5695-701. doi: 10.1021/bi9619841.

引用本文的文献

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening.

Membranes (Basel). 2022 Sep 28;12(10):954. doi: 10.3390/membranes12100954.

Discovery of agonist-antagonist pairs for the modulation of Ca and voltage-gated K channels of large conductance that contain beta1 subunits.

Bioorg Med Chem. 2022 Aug 15;68:116876. doi: 10.1016/j.bmc.2022.116876. Epub 2022 Jun 13.

The interaction of steroids with phospholipid bilayers and membranes.

Biophys Rev. 2021 Dec 2;14(1):163-179. doi: 10.1007/s12551-021-00918-2. eCollection 2022 Feb.

Quantitative Analysis of the Membrane Affinity of Local Anesthetics Using a Model Cell Membrane.

Membranes (Basel). 2021 Jul 30;11(8):579. doi: 10.3390/membranes11080579.

BK channel-forming slo1 proteins mediate the brain artery constriction evoked by the neurosteroid pregnenolone.

Neuropharmacology. 2021 Jul 1;192:108603. doi: 10.1016/j.neuropharm.2021.108603. Epub 2021 May 21.

Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations.

Biophys J. 2018 Mar 27;114(6):1321-1335. doi: 10.1016/j.bpj.2018.01.028.

β-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent.

Biophys J. 2017 Sep 5;113(5):1080-1092. doi: 10.1016/j.bpj.2017.07.010.

Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity.

Molecules. 2017 Aug 18;22(8):1369. doi: 10.3390/molecules22081369.

The Water Permeability and Pore Entrance Structure of Aquaporin-4 Depend on Lipid Bilayer Thickness.

Biophys J. 2016 Jul 12;111(1):90-9. doi: 10.1016/j.bpj.2016.05.039.

The Influence of Lipid Bilayer Physicochemical Properties on Gramicidin A Conformer Preferences.

Biophys J. 2016 Apr 26;110(8):1826-1835. doi: 10.1016/j.bpj.2016.03.020.

本文引用的文献

Regulation of membrane protein function by lipid bilayer elasticity-a single molecule technology to measure the bilayer properties experienced by an embedded protein.

J Phys Condens Matter. 2006 Jul 19;18(28):S1305-44. doi: 10.1088/0953-8984/18/28/S13. Epub 2006 Jun 28.

The influence of drug-like concepts on decision-making in medicinal chemistry.

Nat Rev Drug Discov. 2007 Nov;6(11):881-90. doi: 10.1038/nrd2445.

Single-molecule methods for monitoring changes in bilayer elastic properties.

Methods Mol Biol. 2007;400:543-70. doi: 10.1007/978-1-59745-519-0_37.

Docosahexaenoic acid alters bilayer elastic properties.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9638-43. doi: 10.1073/pnas.0701015104. Epub 2007 May 29.

Bilayer thickness and membrane protein function: an energetic perspective.

Annu Rev Biophys Biomol Struct. 2007;36:107-30. doi: 10.1146/annurev.biophys.36.040306.132643.

GABA(A) receptor function is regulated by lipid bilayer elasticity.

Biochemistry. 2006 Oct 31;45(43):13118-29. doi: 10.1021/bi060734+.

TRPV1 is a novel target for omega-3 polyunsaturated fatty acids.

J Physiol. 2007 Jan 15;578(Pt 2):397-411. doi: 10.1113/jphysiol.2006.121988. Epub 2006 Oct 12.

The receptor concept: pharmacology's big idea.

Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S9-16. doi: 10.1038/sj.bjp.0706457.

Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity.

Mol Pharmacol. 2005 Sep;68(3):680-9. doi: 10.1124/mol.105.013573. Epub 2005 Jun 20.

Lysophospholipid receptors: signaling and biology.

Annu Rev Biochem. 2004;73:321-54. doi: 10.1146/annurev.biochem.73.011303.073731.