Bowsher J G, Williams P A, Clarke I C, Green D D, Donaldson T K
Department of Orthopaedics, Loma Linda University Medical Center, Loma Linda, California 92354, USA.
J Biomed Mater Res B Appl Biomater. 2008 Jul;86(1):253-63. doi: 10.1002/jbm.b.31013.
Our purpose was to compare the wear performance of mechanically enhanced 5Mrad highly crosslinked polyethylene (MEP, ArComXL) hip liners to (control) 3Mrad UHMWPE liners (ArCom) in 36 mm head size. As a more severe synergy of clinically relevant test models, we contrasted wear with custom roughened Co-Cr surfaces (Ra 500 nm) to the standard pristine Co-Cr heads (Ra < 20 nm) using a severe microseparation test mode in our hip simulator. We adopted a previously published model to estimate potential biological activity. On new Co-Cr heads, the MEP liners showed a 47% reduction in volumetric wear a 13% reduction in wear particle size and a 27% reduction in Functional Biological Activity (FBA) compared to our control. On rough Co-Cr heads, the MEP liners showed little advantage in terms of volumetric wear compared with the control. However, the MEP liners overall showed a 38% reduction in FBA compared to the control owing to a larger volume fraction of larger particles. Thus overall the MEP liners appeared to offer advantages in terms of reduced FBA indices.
我们的目的是比较机械增强的5兆拉德高交联聚乙烯（MEP，ArComXL）髋臼内衬与（对照）3兆拉德超高分子量聚乙烯内衬（ArCom）在36毫米股骨头尺寸下的磨损性能。作为临床相关测试模型更严格的协同作用，我们在髋关节模拟器中使用严重微分离测试模式，将定制粗糙化的钴铬表面（粗糙度Ra 500纳米）与标准原始钴铬股骨头（粗糙度Ra < 20纳米）的磨损情况进行对比。我们采用先前发表的模型来估计潜在的生物活性。在新的钴铬股骨头上，与我们的对照相比，MEP内衬的体积磨损减少了47%，磨损颗粒尺寸减少了13%，功能生物活性（FBA）降低了27%。在粗糙的钴铬股骨头上，与对照相比，MEP内衬在体积磨损方面优势不大。然而，由于较大颗粒的体积分数更大，MEP内衬总体上与对照相比FBA降低了38%。因此，总体而言，MEP内衬在降低FBA指数方面似乎具有优势。
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