Morikawa K, Matsumoto O, Tsujimoto M, Katayanagi K, Doi T, Ariyoshi M, Ikehara M, Inaoka T, Ohtsuka E
Protein Engineering Research Institute, Osaka, Japan.
Nucleic Acids Symp Ser. 1991(24):181-4.
T4 endonuclease V is an enzyme responsible for the first step of a pyrimidine-dimer specific excision-repair process. The three-dimensional structure of this enzyme has been determined at 1.6A resolution by X-ray crystallography. The enzyme consists of one single compact domain classified into the all alpha structure. This single domain possesses two distinct catalytic activities, a pyrimidine-dimer glycosylase and an apurinic/apyrimidinic endonuclease. The backbone of the enzyme represents a unique folding scheme incompatible with close packing of alpha-helices. The refined structure suggests possible residues that participate in interactions with DNA.
T4 核酸内切酶 V 是一种负责嘧啶二聚体特异性切除修复过程第一步的酶。该酶的三维结构已通过 X 射线晶体学以 1.6 埃的分辨率确定。该酶由一个单一的紧密结构域组成，归类为全α结构。这个单一结构域具有两种不同的催化活性，即嘧啶二聚体糖基化酶和脱嘌呤/脱嘧啶内切核酸酶。该酶的主链代表一种独特的折叠模式，与α螺旋的紧密堆积不相容。优化后的结构表明了可能参与与 DNA 相互作用的残基。
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