Pera Joanna, Slowik Agnieszka, Dziedzic Tomasz, Pulyk Roman, Wloch Dorota, Szczudlik Andrzej
Department of Neurology, Jagiellonian University, Krakow, Poland.
Cerebrovasc Dis. 2008;25(5):445-9. doi: 10.1159/000126918. Epub 2008 Apr 16.
Oxidative stress plays an important role in vascular pathology and contributes to the pathophysiology of primary intracerebral hemorrhage (PICH). Glutathione peroxidase 1 (GPX1) is a key enzyme of the antioxidant system. Here, we investigated whether a functional C593T polymorphism of GPX1 gene is associated with PICH in a Polish population.
Genotyping was performed in 192 PICH patients and 197 unrelated controls matched for age and sex. All were of Caucasian origin. The C593T GPX1 polymorphism was investigated using the polymerase chain reaction/restriction fragment length polymorphism method.
Multivariable logistic regression analysis revealed a significant association between genotypes containing the T allele and the entire PICH group (OR = 1.53; 95% CI = 1.02-2.29) and lobar PICH (OR = 2.36; 95% CI = 1.31-4.26) but not nonlobar PICH (OR = 1.19; 95% CI = 0.75-1.89).
We found a positive association between the studied GPX1 polymorphism and lobar PICH in a Polish population.
氧化应激在血管病变中起重要作用，并参与原发性脑出血（PICH）的病理生理过程。谷胱甘肽过氧化物酶1（GPX1）是抗氧化系统的关键酶。在此，我们研究了GPX1基因功能性C593T多态性是否与波兰人群中的PICH相关。
对192例PICH患者和197例年龄及性别匹配的无关对照进行基因分型。所有受试者均为白种人。采用聚合酶链反应/限制性片段长度多态性方法研究C593T GPX1多态性。
多变量逻辑回归分析显示，含有T等位基因的基因型与整个PICH组（比值比=1.53；95%可信区间=1.02-2.29）和脑叶型PICH（比值比=2.36；95%可信区间=1.31-4.26）之间存在显著关联，但与非脑叶型PICH无关（比值比=1.19；95%可信区间=0.75-1.89）。
我们发现，在波兰人群中，所研究的GPX1多态性与脑叶型PICH之间存在正相关。
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