miR-17-92簇在发育和疾病中的多种作用。

miRiad roles for the miR-17-92 cluster in development and disease.

作者信息

Mendell Joshua T

机构信息

McKusick-Nathans Institute of Genetic Medicine, Departments of Pediatrics and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Cell. 2008 Apr 18;133(2):217-22. doi: 10.1016/j.cell.2008.04.001.

DOI:10.1016/j.cell.2008.04.001

PMID:18423194

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2732113/

Abstract

MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

摘要

由miR-17-92簇及其旁系同源物编码的微小RNA（miRNA）被认为具有癌基因的作用。这些miRNA的表达促进细胞增殖，抑制癌细胞凋亡，并诱导肿瘤血管生成。新的研究表明，这些miRNA不仅在肿瘤形成过程中发挥重要作用，在心脏、肺和免疫系统的正常发育过程中也起着关键作用。