Sriamornsak Pornsak, Kennedy Ross A
School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
Int J Pharm. 2008 Jun 24;358(1-2):205-13. doi: 10.1016/j.ijpharm.2008.03.009. Epub 2008 Mar 18.
The aim of this paper was to study the swelling and diffusion behaviors of calcium polysaccharide gel (CaPG) films prepared by an interfacial complexation technique, a new gel formation method that allowed calcium ions to diffuse from a source to form gel films with polysaccharide (i.e., alginate or pectin). The dynamic swelling behavior of CaPG films showed that swelling was a function of time. Most CaPG films showed a maximum amount of water absorption during the first few hours. The films swelled less in water and acidic media but extensively swelled in 0.1M NaCl. The rehydration of the dry films in the acidic media or the 0.1M NaCl solution also lead to the extraction of most of the calcium ions from the CaPG within 4h or less. Partitioning and diffusion of a model drug, theophylline (TPL), were measured through CaPG films equilibrated in different media. The partition and diffusion coefficients of TPL through CaPG films were found to vary, depending upon polysaccharide type, concentration and equilibration medium. The results suggest that both partition and pore mechanisms operated concurrently in the transport of TPL through CaPG films equilibrated in different media.
本文旨在研究通过界面络合技术制备的多糖钙凝胶（CaPG）薄膜的溶胀和扩散行为，界面络合技术是一种新的凝胶形成方法，它能使钙离子从一个源扩散，与多糖（如藻酸盐或果胶）形成凝胶薄膜。CaPG薄膜的动态溶胀行为表明，溶胀是时间的函数。大多数CaPG薄膜在前几个小时内表现出最大吸水量。这些薄膜在水和酸性介质中溶胀较少，但在0.1M NaCl中溶胀显著。干膜在酸性介质或0.1M NaCl溶液中复水也会导致在4小时或更短时间内从CaPG中提取出大部分钙离子。通过在不同介质中平衡的CaPG薄膜测量了模型药物茶碱（TPL）的分配和扩散。发现TPL通过CaPG薄膜的分配系数和扩散系数会因多糖类型、浓度和平衡介质而有所不同。结果表明，在不同介质中平衡的CaPG薄膜对TPL的传输过程中，分配和孔隙机制同时起作用。
